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. 2018 Jan;17(1):1493-1498.
doi: 10.3892/mmr.2017.8036. Epub 2017 Nov 13.

Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis

Yulong Wei  1 , Jie Jia  1 , Xin Jin  1 , Wei Tong  1 , Hongtao Tian  1
Affiliations

Resveratrol ameliorates inflammatory damage and protects against osteoarthritis in a rat model of osteoarthritis (V体育官网)

Yulong Wei et al. Mol Med Rep. 2018 Jan.

Abstract (V体育平台登录)

Resveratrol is a non‑flavonoid polyphenol compound with a stilbene structure. As a type of phytoalexin produced under stress in plants, it improves the plant's resistance against pathogens and environment deterioration, and performs important functions beneficial to human health, such as anti‑cancer, anti‑oxidation, regulating blood lipid levels and prolonging life span. The effects of resveratrol were examined in a rat model of osteoarthritis (OA) and observed to ameliorate inflammatory damage and protect against OA. In the present study, resveratrol significantly inhibited the induction of clinical scores in rats with OA. Resveratrol inhibited tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6 and IL‑18 expression levels, and decreased caspase‑3/9 activity in rats with OA. Inducible nitric oxide synthase, nuclear factor (NF)‑κB, phosphorylated‑(p)‑AMP‑activated protein kinase and sirtuin 1 protein expression were significantly suppressed and heme oxygenase 1 (HO‑1) and nuclear factor erythroid 2‑related factor 2 (Nrf‑2) protein expression was stimulated in rats with OA treated with resveratrol. The current results indicate that resveratrol ameliorates inflammatory damage and protects against OA in a rat model of OA via NF‑κB and HO‑1/Nrf‑2 signaling VSports手机版. .

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Figures

Figure 1.
Figure 1.
Resveratrol ameliorates clinical scores in OA rats. Control, control group; OA, OA model group; Resveratrol, resveratrol treatment group. ##P<0.01 vs. control group, **P<0.01 vs. OA model group. OA, osteoarthritis.
Figure 2.
Figure 2.
Resveratrol ameliorates TNF-α, IL-1β, IL-6 and IL-18 expression levels in OA rats. Resveratrol ameliorates (A) TNF-α, (B) IL-1β, (C) IL-6 and (D) IL-18 expression levels in OA rats Control, control group; OA, OA model group; Resveratrol, resveratrol treatment group. ##P<0.01 vs. control group, **P<0.01 vs. OA model group. OA, osteoarthritis. TNF, tumor necrosis factor; IL, interleukin; OA, osteoarthritis.
Figure 3.
Figure 3.
Resveratrol suppresses iNOS, NF-κB, p-AMPK and SIRT1 protein expression in OA rats. (A) Representative western blot images. Quantification of (B) iNOS, (C) p-AMPK, (D) NF-κB and (E) and SIRT1 protein expression levels by resveratrol. Statistical analysis was performed following western blot analysis for iNOS, NF-κB, p-AMPK and SIRT1 protein expression in OA rats. ##P<0.01 vs. control group, **P<0.01 vs. OA model group. OA, osteoarthritis; iNOS, inducible nitric oxide synthase; NF, nuclear factor; AMPK, AMP-activated protein kinase; SIRT1, sirtuin 1.
Figure 4.
Figure 4.
Resveratrol inhibits MDA and SOD levels in OA rats. Effects of resveratrol (A) inhibits MDA and (B) increases SOD levels in OA rats. Control, control group; OA, OA model group; Resveratrol, resveratrol treatment group. ##P<0.01 vs. control group, **P<0.01 vs. OA model group. OA, osteoarthritis; MDA, 3,4-methylenedioxyamphetamine; SOD, superoxide dismutase.
Figure 5.
Figure 5.
Resveratrol induces HO-1 and Nrf-2 protein expression in OA rats. (A) HO-1 protein expression. N (B) Representative western blot images. (C) Nrf-2 protein expression. Control, control group; OA, OA model group; Resveratrol, resveratrol treatment group. ##P<0.01 vs. control group, **P<0.01 vs. OA model group. OA, osteoarthritis; HO-1, heme oxygenase 1; Nrf-2, nuclear factor erythroid 2-related factor 2.
Figure 6.
Figure 6.
Resveratrol reduces caspase-3/9 activity in OA rats. Control, control group; OA, OA model group; Resveratrol, resveratrol treatment group. ##P<0.01 vs. control group, **P<0.01 vs. OA model group. OA, osteoarthritis.
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