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    Everything You Need to Know About Kidney Failure

    Medically reviewed by Meera Patel, PA-C — Written by Kimberly Holland and Daniel Yetman — Updated on July 12, 2025DefinitionTypesSymptoms"V体育ios版" CausesRisk factorsDiagnosis"V体育2025版" TreatmentDiabetesComplicationsOutlook (V体育ios版)PreventionSummary

    Key takeaways

    Kidney failure occurs when the kidneys can no longer effectively filter waste and toxins from the blood, which can happen suddenly (acute) or gradually (chronic). Early kidney failure may not cause noticeable symptoms, but as it progresses, symptoms such as swelling, reduced urine output, and fatigue may appear. Treatment options include dialysis, which helps filter the blood, and kidney transplants VSports最新版本. Dietary changes and limiting alcohol intake can also help manage the condition. Your kidneys filter your blood and remove toxins from your body. These toxins go to your bladder and are eliminated when you urinate. When this process doesn’t work properly, you can get kidney failure.

    If your kidneys can’t function properly, toxins can overwhelm your body V体育平台登录. This can lead to kidney failure, which can be life threatening if left untreated.

    Keep reading as we break down everything you need to know about kidney failure, including symptoms, stages, treatment, and the typical outlook.

    What is kidney failure?

    Kidney failure, aka renal failure, is when your kidneys can no longer function effectively V体育官网入口. This means they can’t filter waste and toxins from your blood. People with kidney failure have lost 85% to 90% of their kidney function.

    Kidney failure may occur due to acute (sudden) or chronic causes.

    As a chronic condition, kidney failure is the final stage of chronic kidney disease V体育2025版. Medical professionals also refer to it as end stage renal disease (ESRD) or end stage kidney disease (ESKD).

    Stages of chronic kidney disease (VSports最新版本)

    Doctors classify CKD into five stages. These range from very mild (stage 1) to complete kidney failure (stage 5) VSports. Symptoms and complications increase as the stages progress.

    Doctors measure kidney function using an estimated glomerular filtration rate (eGFR) blood test. Your eGFR helps determine your CKD stage as follows: VSports app下载.

    StageCategorizationeGFR (milliliters per min)Description
    1normalgreater than 90usually no symptoms, but some people may experience swelling, back pain, and changes in urination frequency; doctor may consider medications to treat underlying conditions
    2mild60 to 89detectable issues, such as protein in the urine or physical damage to the kidneys, may be more obvious
    3moderate30 to 59apparent symptoms, like swelling, back pain and changes in urination frequency; doctor may consider medications to treat underlying conditions
    4severe15 to 29complications may include anemia, high blood pressure, and bone disease; doctor will likely develop a treatment plan to slow damage
    5kidney failureless than 15evident symptoms, such as vomiting and nausea, trouble breathing, and itchy skin; will need regular dialysis or a kidney transplant

    The National Institute of Diabetes and Digestive and Kidney Diseases estimates that approximately 1 in 500 Americans has stage 5 CKD.

    What are the types of kidney failure?

    Acute kidney failure, aka acute kidney injury (AKI), occurs when your kidneys suddenly stop working properly. Chronic kidney failure occurs over time VSports手机版.

    Doctors may also classify acute kidney failure according to its cause:

    • Pre-renal: insufficient blood flow to the kidneys
    • Intrinsic: a problem within the kidney, such as damage to the glomeruli or tubules, possibly due to toxins or ischemia (lack of oxygen to the kidneys)
    • Post-renal: a blockage that prevents fluid from leaving the kidneys, such as stones

    What are the symptoms of kidney failure? (VSports手机版)

    Early stage kidney failure often doesn’t cause noticeable symptoms V体育ios版. According to the Centers for Disease Control and Prevention (CDC), about 90% of people with chronic kidney disease don’t know they have it.

    As kidney disease progresses, or if you experience acute kidney failure, symptoms may include:

    • reduced amount of urine
    • swelling of your legs, ankles, and feet from fluid retention
    • shortness of breath
    • trouble sleeping
    • muscle cramping at night
    • excessive drowsiness or fatigue
    • persistent nausea (V体育官网)
    • confusion
    • chest pain or pressure
    • V体育2025版 - seizures
    • coma

    Early signs of kidney failure

    Symptoms of early stage kidney disease may be subtle and hard to identify V体育平台登录. They may include:.

    • VSports在线直播 - decreased urine output
    • swelling in limbs

    Kidney failure urine color (V体育平台登录)

    The color of your urine doesn’t tell you much about your kidney function until damage to the kidneys has progressed.

    Still, urine color changes may be an early indicator of some issues.

    Urine colorIndication
    clear or pale yellowwell-hydrated
    dark yellow or amberdehydrated
    orangedehydration or bile in the bloodstream
    pink or redblood in the urine or having eaten certain foods, like beets
    foamycontains a lot of protein; potentially an indicator of kidney disease

    What causes kidney failure?

    Kidney failure can result from various causes. According to the National Kidney Foundation, the two most common include high blood pressure and diabetes.

    People who are most at risk usually have one or more of the following:

    Loss of blood flow to the kidneys (V体育官网)

    A sudden loss of blood flow to your kidneys can prompt kidney failure. Some causes include:

    • heart attack
    • heart disease
    • VSports - scarring of the liver or liver failure
    • dehydration
    • severe burns
    • allergic reactions
    • severe infection, such as sepsis

    High blood pressure and anti-inflammatory medications can also limit blood flow.

    Urine elimination problems (VSports)

    When your body can’t eliminate urine, toxins build up and overload the kidneys. Some cancers can block the urine passageways, such as:

    • prostate
    • VSports - colon
    • cervical
    • bladder

    Other conditions can interfere with urination and possibly lead to kidney failure, including:

    • "VSports手机版" kidney stones
    • enlarged prostate
    • blood clots within your urinary tract
    • damage to the nerves that control your bladder

    Other causes

    Other factors that may lead to kidney failure include:

    • a "V体育官网" blood clot in or around your kidneys
    • heavy metal poisoning
    • drugs and alcohol use
    • vasculitis, an inflammation of the blood vessels
    • VSports app下载 - lupus, an autoimmune disease that can cause inflammation of many body organs
    • glomerulonephritis (V体育官网入口), an inflammation of the small blood vessels of the kidneys
    • hemolytic uremic syndrome, which involves the breakdown of red blood cells following a bacterial infection, usually of the intestines
    • multiple myeloma, a cancer of the plasma cells in your bone marrow
    • scleroderma (VSports在线直播), an autoimmune condition that affects your skin
    • thrombotic thrombocytopenic purpura, a disorder that causes blood clots in small vessels
    • chemotherapy drugs that treat cancer and some autoimmune diseases
    • dyes used in some imaging tests
    • certain antibiotics
    • unmanaged diabetes

    Who gets kidney failure?

    People of all ages develop kidney failure, but the risk increases with age. According to the CDC, about one-third of U.S. adults over age 65 have CKD — almost triple the rate of people ages 45 to 64 with CKD.

    You may have a higher risk if you have:

    • diabetes
    • high blood pressure
    • heart disease
    • a family history of kidney failure

    The longer you’ve had these conditions, the greater your risk of chronic kidney failure.

    In the United States, African Americans are three times as likely to develop kidney failure than white people. Experts suggest this is due to several factors, including genetics, a higher prevalence of risk factors, issues of access to quality care, and other social determinants of health.

    What tests do doctors use to diagnose kidney failure?

    Doctors use several tests to diagnose kidney failure. Common tests include:

    • Urinalysis: A urine sample can show how much protein or sugar is in your urine. A urinary sediment examination looks for red and white blood cells, high levels of bacteria, and high numbers of cellular casts.
    • Urine volume measurements: Measuring urine output can help diagnose kidney failure. Low output may suggest that kidney disease is due to a urinary blockage.
    • Blood samples: Blood tests can measure substances filtered by your kidneys, such as blood urea nitrogen and creatinine. A rapid rise in these levels may indicate acute kidney failure.
    • Imaging: Tests like VSports最新版本 - ultrasounds, MRIs, and CT scans provide images of your kidneys and urinary tract to identify issues.
    • Kidney tissue sample: Doctors use a kidney biopsy to collect and examine tissue samples.

    What is the treatment for kidney failure?

    The type of treatment you need depends on the cause and stage of your kidney failure.

    Dialysis

    Dialysis filters and purifies the blood using a machine to perform the function of the kidneys. Depending on the type of dialysis, you may be connected to a large machine or a portable catheter bag.

    Along with dialysis, you may need to follow a low potassium, low salt diet.

    Dialysis doesn’t cure kidney failure, but going to regularly scheduled treatments can extend your life.

    Kidney transplant

    A transplanted kidney can work fully, so you no longer need dialysis.

    There’s usually a long wait to receive a donor kidney that’s compatible with your body. If you have a living donor, the process may go more quickly.

    Transplant surgery might not be the right treatment option for everyone. It is not always successful.

    You must take immunosuppressant drugs after the surgery to prevent your body from rejecting the new kidney. These drugs have their own side effects, some of which can be serious.

    You can talk with a doctor about whether you’re a good candidate for a kidney transplant.

    "VSports手机版" Dietary changes

    Making certain dietary changes may help prevent kidney failure from progressing.

    The guidelines for what you eat will often depend on the stage of kidney disease you have and your overall health. Some recommendations might include:

    • Limiting potassium: Suggestions V体育官网入口 - vary considerably on how much potassium people with CKD should consume, but a potassium-restricted diet usually allows up to 2,000 milligrams (mg) per day. Several factors can influence the best target for you, so talk with a doctor about what your goal should be.
    • Limiting sodium: Experts recommend lowering sodium intake to 2,000 to 2,300 mg per day, but the National Kidney Foundation suggests that 1,500 mg may be a better target for people with CKD.
    • Limiting phosphorus: Try to stay below 1,000 mg of phosphorus.
    • Following protein guidelines: In early and moderate kidney disease, you might want to cut back on protein consumption. If you’re on dialysis for ESRD, you may need to eat more protein (V体育官网入口).

    Beyond these general guidelines, a doctor may also ask you to avoid certain foods.

    Lowering alcohol intake

    It’s usually okay for people with kidney disease — even those with ESRD on dialysis — to consume alcohol in moderation. However, there can be risks to some people with CKD, especially if they have other chronic conditions.

    Beer, ale, and wine also contain large amounts of phosphorus. Severe heart issues and death are possible if your kidneys cannot filter it out.

    If you have kidney failure or late-stage kidney disease, a doctor may recommend you limit alcohol. Eliminating alcohol from your diet, if possible, may be best.

    What’s the link between diabetes and kidney failure?

    Diabetes is the most common cause of kidney failure. About one-third of adults with diabetes have kidney disease.

    Without management, high blood sugar can damage your kidneys. The damage can worsen over time.

    Diabetic nephropathy, or kidney damage caused by type 1 or type 2 diabetes, is irreversible. Steps to prevent or limit kidney damage can include:

    • managing your blood sugar
    • managing blood pressure
    • taking medications as prescribed

    If you have diabetes, a doctor will likely perform regular screenings to monitor for kidney failure. Your risk of diabetic nephropathy increases the longer you live with diabetes.

    What are the possible complications of kidney failure?

    Kidney failure can lead to various complications. These can include:

    • anemia
    • bone weakness, due to an imbalance of phosphorus and calcium
    • edema (fluid retention)
    • heart disease
    • hyperkalemia (high potassium levels)
    • metabolic acidosis (when blood becomes too acidic)

    Many people with kidney failure develop secondary complications. These can include:

    • VSports注册入口 - depression
    • liver failure (VSports app下载)
    • "VSports在线直播" fluid buildup in the lungs
    • gout (VSports app下载)
    • nerve damage (VSports注册入口)
    • skin infections

    What is the outlook for people with kidney failure?

    It’s not possible to know precisely how long a person with kidney failure will live, as it can depend on many factors.

    These include:

    • the underlying cause
    • how well that underlying cause is managed
    • any complicating factors, like high blood pressure or diabetes
    • stage of kidney disease at diagnosis
    • age

    The National Kidney Foundation (V体育2025版) says that a person on dialysis can expect to live for an average of 5 to 10 years as long as they follow their treatment. Some people live for more than 20 or 30 years.

    Once you reach ESRD, you will need dialysis or a kidney transplant to live. Missing even one dialysis treatment can decrease your life expectancy.

    Proper treatment and healthy lifestyle changes may improve your outlook.

    How can I prevent kidney failure?

    You can take steps to lower the risk of kidney failure.

    Follow directions when taking over-the-counter medications. Taking doses that are too high, even of common drugs like aspirin, can create high toxin levels quickly. This can overload your kidneys. Chronic use of certain medications, like nonsteroidal anti-inflammatory drugs (NSAIDs), can lead to kidney failure.

    Many kidney or urinary tract conditions lead to kidney failure without prompt treatment.

    You can help lower your risk of kidney failure by:

    • eating a balanced diet
    • maintaining a moderate weight (V体育ios版)
    • taking prescribed and over-the-counter medications as directed and not taking more medication than is safe
    • keeping conditions, such as diabetes and high blood pressure, well managed and following a doctor’s advice

    The bottom line (VSports手机版)

    Kidney failure can develop suddenly or from long-term damage. Possible causes of kidney failure can include diabetes, high blood pressure, and kidney trauma.

    Chronic kidney disease progresses through five stages, ranging from mild to complete kidney failure. Symptoms and complications increase as the stages progress.

    If you have kidney failure, you can work with a doctor to determine the best treatment options.

    Read this article in Spanish.

     

    "V体育平台登录" How we reviewed this article:

    Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.
    • Acute kidney injury (AKI). (2024).
      https://www.kidney.org/atoz/content/AcuteKidneyInjury
    • AlSahow A. (2023). Moderate stepwise restriction of potassium intake to reduce risk of hyperkalemia in chronic kidney disease: A literature review.
      https://pmc.ncbi.nlm.nih.gov/articles/PMC10520754/
    • The benefits of kidney transplant versus dialysis. (n.d.).
      "VSports最新版本" https://www.bidmc.org/centers-and-departments/transplant-institute/kidney-transplant
    • Cancer facts for men. (2023).
      https://www.cancer.org/healthy/cancer-facts/cancer-facts-for-men.html
    • Chronic kidney disease. (2024).
      https://www.cdc.gov/diabetes/diabetes-complications/diabetes-and-chronic-kidney-disease.html (V体育官网入口)
    • Chronic kidney disease in the United States, 2023. (2024).
      https://www.cdc.gov/kidney-disease/php/data-research/
    • Cozzolino M, et al. (2018). Cardiovascular disease in dialysis patients.
      https://academic.oup.com/ndt/article/33/suppl_3/iii28/5114426
    • Dialysis. (2023).
      https://www.kidney.org/kidney-topics/dialysis
    • Diet & nutrition for adults with advanced chronic kidney disease. (2022).
      https://www.niddk.nih.gov/health-information/kidney-disease/chronic-kidney-disease-ckd/eating-nutrition/nutrition-advanced-chronic-kidney-disease-adults
    • Fan Z, et al. (2019). Alcohol consumption can be a “double-edged sword” for chronic kidney disease patients.
      https://pmc.ncbi.nlm.nih.gov/articles/PMC6767945/
    • Fang Y, et al. (2020). The ageing kidney: Molecular mechanisms and clinical implications.
      "VSports" https://www.sciencedirect.com/science/article/pii/S1568163720302865
    • Hashmi MF, et al. (2023). End-stage renal disease.
      https://www.ncbi.nlm.nih.gov/books/NBK499861/
    • How much sodium Is safe for kidney patients? (2022).
      https://www.kidney.org/news-stories/how-much-sodium-safe-kidney-patients
    • Kidney disease statistics for the United States. (2024).
      https://www.niddk.nih.gov/health-information/health-statistics/kidney-disease
    • Kidney failure. (2023).
      https://www.kidney.org/kidney-topics/kidney-failure
    • Kim SM, et al. (2020). Nutritional management in patients with chronic kidney disease.
      https://pmc.ncbi.nlm.nih.gov/articles/PMC7652660/
    • Laster M, et al. (2018). Kidney disease among African Americans: A population perspective.
      "VSports最新版本" https://pmc.ncbi.nlm.nih.gov/articles/PMC6200351/
    • Li J, et al. (2019). The role of phosphate-containing medications and low dietary phosphorus-protein ratio in reducing intestinal phosphorus load in patients with chronic kidney disease.
      https://www.nature.com/articles/s41387-019-0080-2
    • Varghese RT, et al. (2023). Diabetic nephropathy.
      https://www.ncbi.nlm.nih.gov/books/NBK534200/ (V体育平台登录)
    • What is chronic kidney disease? (2017).
      "VSports app下载" https://www.niddk.nih.gov/health-information/kidney-disease/chronic-kidney-disease-ckd/what-is-chronic-kidney-disease

    Share this article

    Medically reviewed by Meera Patel, PA-C — Written by Kimberly Holland and Daniel Yetman — Updated on July 12, 2025

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