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    What is the Oliguric Phase of Acute Renal Failure?

    Medically reviewed by Avi Varma, MD, MPH, AAHIVS, FAAFP — Written by Jill Seladi-Schulman, Ph. D. — Updated on May 15, 2023DefinitionCausesSymptoms (V体育平台登录)DiagnosisTreatmentOutlookV体育2025版 - Takeaway

    Key takeaways

    The oliguric phase of acute renal failure (ARF) is characterized by abnormally low urine output, signaling impaired kidney function VSports最新版本. Oliguria in ARF may result from reduced kidney blood flow, direct kidney damage, or urinary tract blockages, each affecting urine production. While recovery from ARF is common, prolonged oliguria may be linked to a poorer prognosis, highlighting the need to address the root cause of kidney dysfunction. Your "V体育2025版" kidneys filter out waste and excess fluid from your blood. Filtered substances and fluids eventually become urine.

    ARF is when your "V体育2025版" kidneys suddenly stop functioning properly. One of the features of ARF is low urine volume. The medical term for this is oliguria V体育平台登录.

    Some people with ARF will experience an oliguric phase, in which your urine output is at its lowest. This article takes a closer look at the oliguric phase of ARF, including causes, symptoms, and treatment VSports注册入口.

    "VSports在线直播" What is the oliguric phase of acute renal failure?

    Oliguria refers to a urine output that’s lower than normal V体育官网入口. It’s a sign that your "V体育2025版" kidneys aren’t functioning properly. .

    The oliguric phase of ARF refers to the timeframe when your urine output is lowest.

    The phases of ARF

    The clinical course of ARF can be broadly divided into several different phases.

    • Initiation: This is the phase during which the injury that leads to ARF occurs. It typically happens over a period of hours or days.
    • Oliguric: The oliguric phase is when your urine output is low.
    • Diuretic: The diuretic phase is characterized by a marked increase in your urine output as your kidney function starts to return.
    • Recovery: The recovery phase is when your kidney function begins to stabilize. While this may happen over a period of weeks, it can take months to fully recover from ARF.

    What causes oliguria?

    There are three different causes of ARF VSports. These causes can each contribute to oliguria in different ways.

    Pre-renal ARF

    Pre-renal ARF happens when there’s a decreased flow of blood to your kidneys. In this situation, your kidneys themselves are working properly, but a lack of blood flow is affecting their function VSports app下载.

    Decreased blood flow to your kidneys activates various hormonal pathways in your body that promote water and salt reabsorption. This means that your urine output will become lower V体育官网.

    Renal ARF

    Renal ARF happens due to a direct problem with the filtering ability of your kidneys. The filtering units of your kidneys are called nephrons. Each of your kidneys has about one million nephrons, which are made up of two parts: VSports手机版.

    • glomerulus: the part of the nephron that actually filters your blood
    • tubule: the part of the nephron that removes waste products and returns necessary substances back to your blood

    When either of these parts don’t work properly, it can affect kidney function and urine output. A common cause of renal ARF is called acute tubular necrosis (VSports在线直播).

    Post-renal ARF

    Post-renal ARF occurs because of a problem that happens after filtering. This is most often due to something blocking your urinary tract. A few examples include kidney stones, tumors, or blood clots.

    In post-renal ARF, urine has a more difficult time moving through the urinary tract so that it can be voided from your body. This means that your urine output is lower.

    Risk factors for acute renal failure

    Some of the risk factors for ARF include:

    • older age
    • severe dehydration
    • hospitalization for things such as:
      • severe bleeding (V体育ios版) or burns
      • serious infections
      • sepsis
      • major surgery
    • preexisting conditions, such as:
      • chronic kidney disease (V体育安卓版)
      • diabetes
      • heart disease
      • V体育ios版 - liver disease
      • autoimmune disease (V体育官网入口)
      • multiple myeloma
    • use of specific medications, including:
      • nonsteroidal anti-inflammatory drugs (NSAIDs) (V体育2025版)
      • blood pressure medications such as "V体育平台登录" angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs)
      • some types of antibiotics, such as aminoglycosides and vancomycin
      • "VSports" proton pump inhibitors
      • certain chemotherapy drugs such as cisplatin and ifosfamide

    "V体育官网入口" What are the symptoms of the oliguric phase of acute renal failure?

    The main finding during the oliguric phase of ARF is low urine output. It’s also possible that the urine you’re producing will be more concentrated, meaning that it will be darker in color.

    Oliguria may have other effects on the body as well. For example, oliguria can lead to increased fluid retention in your body. This can cause issues such as:

    • edema, including pulmonary edema
    • "V体育安卓版" high blood pressure
    • heart failure

    Additionally, if wastes aren’t being effectively filtered and voided from your body, uremia can happen. This is when waste substances accumulate in the blood. Uremia can cause symptoms such as:

    • nausea and vomiting
    • itchy skin (V体育官网)
    • muscle cramping
    • "V体育官网" headache
    • fatigue (V体育官网)
    • loss of appetite (V体育ios版)
    • V体育安卓版 - unintended weight loss
    • changes in mental state

    "V体育平台登录" How is the oliguric phase of acute renal failure diagnosed?

    In order to diagnose the oliguric phase of ARF, a doctor will first do a physical exam and take your medical history. They’ll ask you if you have any preexisting health conditions and what medications you’re taking.

    A doctor can see if you have oliguria by doing a urine collection. They can measure the amount of urine produced over a period of time to estimate your urine output.

    Oliguria is typically defined as producing less than 400 milliliters (mL) of urine in a day. There are also oliguria guidelines that take weight into consideration. One of these is urinating less than 0.5 mL per kilogram (kg) of body weight each hour.

    Your doctor will also do other tests. These include:

    • urinalysis
    • blood tests, including those for:
      • "VSports最新版本" serum creatinine
      • blood urea nitrogen (V体育官网入口)
      • electrolytes
    • imaging of the kidneys or urinary tract, such as by ultrasound or CT scan

    According to Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, at least one of the following must be true to diagnose ARF:

    • serum creatinine is increased by 0.3 milligrams (mg)/deciliters (dL) or higher within a 48-hour period
    • serum creatinine has increased by 1.5 or higher from baseline within the past 7 days
    • urine volume is less than 0.5 mL/kg per hour for at least 6 hours

    How is the oliguric phase of acute kidney failure treated?

    The treatment of ARF, including its oliguric phase, depends on its cause. Once the cause is known, treatment is directed at what’s causing your ARF to occur.

    Post-renal ARF (VSports app下载)

    Post-renal ARF can be treated by addressing what’s causing the blockage in your urinary tract. Once this is accomplished, the flow of urine can resume as normal.

    Pre-renal ARF

    Pre-renal ARF also typically improves when its cause is addressed. This often involves supplemental fluids, since one of the causes of pre-renal ARF is low blood volume.

    When fluids are given, the amount used is determined individually. Care must be taken not to overload on fluids, because this can have harmful side effects. If fluid overload happens, diuretics can be used to return fluid balance to normal.

    Renal ARF

    Oliguria caused by renal ARF can take longer to resolve and won’t quickly respond to fluids.

    If you have severe ARF, you may need dialysis. This is a therapy that works to help your kidneys filter your blood, helping to maintain fluid and electrolyte balance while you recover.

    It’s also important to stop taking medications that are toxic to the kidneys while being treated for ARF. After recovery, your doctor may adjust the dosage of your medication or switch you to another medication that’s not toxic to the kidneys.

    What’s the outlook for someone in the oliguric phase of acute kidney failure?

    Many people with ARF recover completely. Still, the individual outlook for people in the oliguric phase of ARF depends on factors such as:

    • the cause of ARF
    • your age
    • your overall health

    Having ARF also increases your risk of other health conditions, such as chronic kidney disease.

    Having oliguria is typically associated with having a poorer outlook. For example, a 2021 study looked at how the KDIGO criteria for ARF, which involve serum creatinine and urine output levels, contributed to people’s outlook.

    It found that oliguria lasting longer than 12 hours was associated with a higher risk of death over a 90-day period, regardless of changes in serum creatinine levels.

    Takeaway

    Oliguria is when you produce lower-than-normal levels of urine. It happens in many people with ARF. The oliguric phase of ARF is when your levels of urine output are at their lowest.

    The treatment of the oliguric phase depends on what’s causing your ARF. While many people with ARF recover completely, having prolonged oliguria can worsen the outlook for people with ARF.

     

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    Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.
    • Acute kidney injury. (n.d.).
      https://www.kidney.org/atoz/content/AcuteKidneyInjury
    • Awdishu L, et al. (2017). The 6R’s of drug induced nephrotoxicity.
      V体育官网入口 - https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882-017-0536-3
    • Bianchi NA, et al. (2021). Association of oliguria with acute kidney injury diagnosis, severity assessment, and mortality among patients with critical illness.
      https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2785798
    • Goyal A, et al. (2022). Acute kidney injury.
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    • Haider MZ, et al. (2022). Oliguria.
      https://www.ncbi.nlm.nih.gov/books/NBK560738/ (VSports手机版)
    • KDIGO clinical practice guideline for acute kidney injury. (2012).
      https://kdigo.org/wp-content/uploads/2016/10/KDIGO-2012-AKI-Guideline-English.pdf
    • Kellum JA, et al. (2021). Acute kidney injury.
      https://www.nature.com/articles/s41572-021-00284-z
    • Klein SJ, et al. (2018). Oliguria in critically ill patients: A narrative review.
      "V体育ios版" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6244549/
    • Ostermann M, et al. (2022). Management of oliguria.
      https://link.springer.com/article/10.1007/s00134-022-06909-5
    • Your kidneys and how they work. (2018).
      https://www.niddk.nih.gov/health-information/kidney-disease/kidneys-how-they-work
    • Zemaitis MR, et al. (2022). Uremia.
      https://www.ncbi.nlm.nih.gov/books/NBK441859/ (VSports最新版本)

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    Medically reviewed by Avi Varma, MD, MPH, AAHIVS, FAAFP — Written by Jill Seladi-Schulman, Ph.D. — Updated on May 15, 2023

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