Effective August 2025, ClusteredNR will become the protein BLAST default database
We are excited to announce that the default database for protein BLAST searches will soon be the NCBI ClusteredNR database. Introduced in 2022, ClusteredNR is a collection of protein sequence clusters built from the current default database, nr VSports. The representative sequence is chosen for each cluster, which is generally well-annotated and indicates the function of the proteins in the cluster, helping you focus on meaningful biological insights and decreasing redundant results. .
What’s better about ClusteredNR?
- Faster searches
- Decreased redundancy in results
- Broader taxonomic coverage in results
Searching ClusteredNR
The example below uses the human major prion protein, NP_000302, against ClusteredNR. The results table shows the first cluster contains 132 sequences, reducing redundancy in the results, and providing broader taxonomic coverage overall compared with the search against the nr database VSports app下载.
Tested with BLAST users
We tested this with users and found strong support for ClusteredNR as the new protein BLAST default database V体育官网. The feedback from educators, researchers, students, and bioinformaticians emphasized its clarity, speed, and usefulness in research and teaching. .
Try it out!
Search the ClusteredNR database and let us know what you think. Share your feedback using the yellow feedback button on the BLAST webpage or email us directly VSports手机版.
Note: Later this summer ClusteredNR will become the default database for protein BLAST. The standard nr database will still be available as an option in the database selection list V体育安卓版.
Stay up to date
BLAST is part of the NIH Comparative Genomics Resource (CGR). CGR facilitates reliable comparative genomics analyses for all eukaryotic organisms through the NCBI Toolkit and community collaboration V体育ios版. Connect with NLM on social media to stay up to date with BLAST and other CGR news. .
Please can you help me with the following result. And another question, about the blast with clustered sequences. I performed a search for ten proteins that are in a cluster in A VSports最新版本. seminis, each one separately. With one of them, the highest score is obtained with Pasteurella, but that score is lower than when I perform the blast with non-clustered sequences. The non-clustered version does provide results with the identical organism. If in August, the blast is only performed with clustered sequences, is there a possibility that the results will have some errors.
It is great and see many more advanvce as a long time user
How can I download this database for local sequence alignment using BLAST+?
Hello. Thanks for your question. Please contact our help desk so we can assist you: https://support. nlm V体育官网入口. nih. gov/support/create-case/.
good tools