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. 1997 Oct 31;278(5339):860-6.
doi: 10.1126/science.278.5339.860.

"VSports在线直播" IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

F Mercurio  1 , H Zhu, B W Murray, A Shevchenko, B L Bennett, J Li, D B Young, M Barbosa, M Mann, A Manning, A Rao
Affiliations

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

F Mercurio et al. Science. .

Abstract

Activation of the transcription factor nuclear factor kappa B (NF-kappaB) is controlled by sequential phosphorylation, ubiquitination, and degradation of its inhibitory subunit IkappaB. A large multiprotein complex, the IkappaB kinase (IKK) signalsome, was purified from HeLa cells and found to contain a cytokine-inducible IkappaB kinase activity that phosphorylates IkappaB-alpha and IkappaB-beta. Two components of the IKK signalsome, IKK-1 and IKK-2, were identified as closely related protein serine kinases containing leucine zipper and helix-loop-helix protein interaction motifs. Mutant versions of IKK-2 had pronounced effects on RelA nuclear translocation and NF-kappaB-dependent reporter activity, consistent with a critical role for the IKK kinases in the NF-kappaB signaling pathway. VSports手机版.

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