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Comparative Study
. 1995 Apr;71(4):705-11.
doi: 10.1038/bjc.1995.138.

The interaction with tubulin of a series of stilbenes based on combretastatin A-4

J A Woods  1 , J A Hadfield, G R Pettit, B W Fox, A T McGown
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Free PMC article
Comparative Study

The interaction with tubulin of a series of stilbenes based on combretastatin A-4 (V体育官网入口)

J A Woods et al. Br J Cancer. 1995 Apr.
Free PMC article

Abstract

A series of stilbenes, based on combretastatin A-4, were synthesised. A structure-activity study was carried out to characterise the interaction of these agents with tubulin. The substitution of small alkyl substituents for the 4'-methoxy group of combretastatin A-4 and the loss of the 3'-hydroxyl group does not have a major effect on the interaction with tubulin. trans-Stilbenes were shown to bind tubulin, but do not inhibit microtubule assembly VSports手机版. This work, together with previous studies, has been used to propose an idealised structure for a tubulin-binding agent of this type. .

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References (V体育安卓版)

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