Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site VSports app下载. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2025 Sep 19:28:e250047.
doi: 10.1590/1980-549720250047. eCollection 2025.

Trends in incidence, mortality, and lethality due to meningitis in children and teenagers in Brazil: a nationwide time-series study from 2002 to 2022

Alessandro Vidal de Oliveira  1 , Geovanna Barros Rocha  1 , Ana Luiza Nepomuceno Sampaio  1 , Ana Lucy Peixoto Rabelo  1
Affiliations

Trends in incidence, mortality, and lethality due to meningitis in children and teenagers in Brazil: a nationwide time-series study from 2002 to 2022

Alessandro Vidal de Oliveira et al. Rev Bras Epidemiol. .

Abstract
in English, Portuguese

Objective: The aim of this study was to analyze the trends in incidence, mortality, and lethality rates due to meningitis in children and teenagers aged 0-19 years in Brazil and its regions by sex from 2002 to 2022. VSports手机版.

Methods: This is a time-series study of the cases and deaths due to meningitis with data from the Notifiable Diseases Information System. We estimated the average annual percent change (AAPC) and its 95% confidence interval (95%CI) via Joinpoint regression, in addition to comparing the Brazilian Federative Units' AAPCs by a pairwise coincidence test. V体育安卓版.

Results: There were 274,500 cases and 17,162 deaths during the analyzed period, with downward trends both in Brazil and its regions regarding the incidence and mortality rates. In Brazil, the lowest AAPC in incidence was among males (AAPC=-5. 7, 95%CI -7. 1 to -4. 2), whereas the lowest AAPC in mortality was among females (AAPC=-8. 2, 95%CI -9. 1 to -7. 3). There were greater reductions in the incidence among males in all regions, except for the Central-West. Regarding the mortality rate, Northeast (AAPC=-9. 6, 95%CI -10. 6 to -8. 5), South (AAPC=-8 V体育ios版. 1, 95%CI -9. 8 to -6. 3), and Central-West (AAPC=-8. 5, 95%CI -10. 7 to -6. 3) showed their lowest AAPCs among females. There were significant differences in trends between males and females, mostly regarding incidence rates. .

Conclusion: Meningitis remains a concerning disease in Brazil, despite the downward trend in the country and its regions VSports最新版本. It highlights the perpetuation of health inequalities, which reverberate in the levels of vaccination coverage and in the success of vaccination campaigns, impeding this disease's proper control. .

Objetivo:: Analisar a tendência temporal da incidência, da mortalidade e da letalidade de meningite em crianças e adolescentes de 0-19 anos no Brasil e em suas regiões por sexo de 2002 a 2022. Métodos: Trata-se de um estudo de séries temporais dos casos de meningite e óbitos pela doença com dados do Sistema de Informação de Agravos de Notificação V体育平台登录. Estimaram-se a variação percentual anual média (VPAM) e seu intervalo de 95% de confiança (IC95%) por regressão joinpoint, além de comparar as VPAMs das unidades federativas por teste pareado de coincidência. .

Resultados:: Houve 274. 500 casos e 17. 162 óbitos durante o período analisado, com tendência decrescente no Brasil e em suas regiões tanto na incidência quanto na mortalidade. No Brasil, a menor VPAM da incidência foi no sexo masculino (VPAM=-5,7; IC95% -7,1 a -4,2), enquanto o menor VPAM da mortalidade foi no feminino (VPAM=-8,2; IC95% -9,1 a -7,3). Houve maior redução de incidência no sexo masculino, com exceção do centro-Oeste. Quanto à mortalidade, nordeste (VPAM=-9. 6; IC95% -10,6 a -8,5), sul (VPAM=-8,1; IC95% -9,8 a -6,3) e centro-oeste (VPAM=-8,5; IC95% -10,7 a -6,3) apresentaram menores VPAMs entre o sexo feminino. Houve diferenças significativas entre as tendências entre os sexos masculino e feminino, sobretudo na incidência VSports注册入口. .

Conclusão:: A meningite ainda é uma doença preocupante no Brasil, apesar das tendências decrescentes no país V体育官网入口. Há manutenção de iniquidades na saúde, as quais reverberam na cobertura vacinal e no sucesso das campanhas vacinais, impedindo o controle adequado da doença. .

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTERESTS: nothing to declare

Figures

Figure 1
Figure 1. (A) Temporal series of the age-adjusted incidence rates and (B) the age-adjusted mortality rates per 100,000 population due to meningitis according to the region of .residence and sex, Brazil, 2002-2022.
Figure 2.
Figure 2.. (A) Temporal series of the lethality rates due to meningitis and (B) their respective trends according to the etiology, Brazil, 2002-2022.
Figure 3.
Figure 3.. Differences in the trends of (A) the age-adjusted incidence and (B) mortality rates due to meningitis between males and females according to the pairwise coincide test, Brazil, 2002-2022.
See this image and copyright information in PMC

References

    1. Magalhães RS, Santos MS. Perfil epidemiológico da meningite bacteriana no Município de Vitória da Conquista - Bahia, no período de 2008 a 2015. Rev Ciênc Méd Biol. 2018;17(1):33–39. doi: 10.9771/cmbio.v17i1.20325. - DOI
    1. Kmetzsch CI, Schermann MT, Santana JCB, Estima CL, Faraco FJ, Silva CM, et al. Meningites por Haemophilus influenzae b após a implantação da vacina específica. J Pediatr (Rio J) 2003;79(6):530–536. doi: 10.1590/S0021-75572003000600012. - VSports在线直播 - DOI - PubMed
    1. Fontaneli CR. Incidência de meningite na Região Metropolitana de Goiânia. [26 mar. 2024];Rev Eletr Farm [Internet] 2006 3(2):25–27. Available in: https://revistas.ufg.br/REF/article/view/2100 .
    1. GBD 2016 Meningitis Collaborators Global, regional, and national burden of meningitis, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2018;17(12):1061–1082. doi: 10.1016/s1474-4422(18)30387-9. - DOI (V体育安卓版) - PMC - PubMed
    1. Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Coordenação-Geral de Desenvolvimento da Epidemiologia em Serviços . Guia de Vigilância em Saúde: volume único. 5ª ed. Brasília: Ministério da Saúde; 2022. [26 mar. 2024]. [Internet] Disponível em: https://bvsms.saude.gov.br/bvs/publicacoes/guia_vigilancia_saude_5ed_rev... .