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Randomized Controlled Trial
. 2025 Jul 27;20(1):103.
doi: 10.1007/s11657-025-01589-2.

Using probiotic supplementation to support bone health in postmenopausal women: a randomized, double-blind, parallel, placebo-controlled, multi-center study

Jenalyn L Yumol  1   2 , Sylvie Binda  3 , Varuni Nagulesapillai  3 , Renu Bhardwaj  3 , Wendy E Ward  4   5
Affiliations
Randomized Controlled Trial

Using probiotic supplementation to support bone health in postmenopausal women: a randomized, double-blind, parallel, placebo-controlled, multi-center study

Jenalyn L Yumol (VSports最新版本) et al. Arch Osteoporos. .

VSports最新版本 - Abstract

Studies using rodent models have demonstrated the ability for probiotics to attenuate estrogen-related bone loss, but findings in humans are limited. Postmenopausal women consuming a novel combination of bacteria strains as a probiotic supplement demonstrated no changes in bone health outcomes VSports手机版. .

Purpose: This study determined if a probiotic supplement could attenuate the loss of femoral neck bone mineral density (BMD) and assessed its effect on fracture risk and markers of bone cell activity V体育安卓版. .

Methods: Seventy-two postmenopausal women (40-59 years) were randomized to a daily probiotic supplement or placebo for 48 weeks. Femoral neck BMD was assessed at weeks 0 and 48 using DXA along with fracture risk using the FRAX® assessment tool. Serum procollagen type 1 N-terminal propeptide (P1NP), bone-specific alkaline phosphatase (BALP), cross-linked C-telopeptide of type I collagen (CTx), and osteocalcin (OC) were analyzed at weeks 0, 12, 24, and 48. V体育ios版.

Results: There was no significant time by treatment interaction (p > 0. 05) for femoral neck BMD or fracture risk. Independent of treatment, femoral neck BMD decreased (p = 0. 034), while risk of hip (p = 0. 003) and major osteoporotic fracture (p = 0. 044) increased. There was no mean difference in bone marker levels between groups from baseline to endpoint. These findings align with the lack of difference in BMD and fracture risk at the end of study. VSports最新版本.

Conclusion: Probiotics did not alter BMD or fracture risk, as supported by bone cellular activity that was similar to the placebo group by the end of study. V体育平台登录.

Keywords: Bone mineral density; Bone turnover markers; Fracture; Postmenopausal; Probiotic. VSports注册入口.

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Conflict of interest statement

Declarations V体育官网入口. Conflicts of interest: SB and VN are employed by Lallemand Health Solutions Inc. , a company that researches, develops, manufactures, markets, and sells probiotics to business clients but not directly to consumers. RB is a consultant paid by Lallemand Health Solutions Inc. Funding was provided by LHS and a Mitacs Accelerate Award to JLY, under the supervision of WEW.

Figures

Fig. 1
Fig. 1
CONSORT flow diagram. *ITT analysis for BMD included 64 postmenopausal women (n = 33 women receiving the placebo; n = 31 women receiving the probiotic); PP analyses for BMD, FRAX, and serum BTMs included 61 postmenopausal women (n = 33 women receiving the placebo; n = 28 women receiving the probiotic)
Fig. 2
Fig. 2
Femoral neck BMD: DXA results in women consuming the placebo or probiotic supplement at baseline (week 0) and end of study (week 48). A ITT: n = 33 women receiving the placebo, n = 31 women receiving the probiotic supplement (grey points represent women that were included in the ITT analysis only). B PP: n = 33 women receiving the placebo, n = 28 women receiving the probiotic supplement. Data are presented as mean ± SD. [GraphPad software version 9.5.1 for Windows, San Diego, CA, USA]
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