Objective: Continuous research on the structure and function of intestinal microecology has confirmed the association between gut microbiota and the occurrence, development, and outcome of allergic diseases VSports手机版. Here, we explored the genetic causality between gut microbiota and rhinitis. .

Methods: We conducted a two-sample Mendelian Randomization (MR) study to investigate the genetic causal relationship between gut microbiota and allergic rhinitis and vasomotor rhinitis. Genetic variations in the human gut microbiota were obtained from the summary statistics of the MiBioGen study V体育安卓版. Genome-wide summary statistics of rhinitis were obtained from the FinnGen consortium. The causal effect between gut microbiota and rhinitis was assessed using the inverse variance weighted, MR-Egger regression, and weighted median methods. In addition, sensitivity analyses were conducted using different methods, including maximum likelihood, simple mode, and weighted model methods. .

Results: The IVW approach revealed a causal association of the genus Ruminococcus gauvreauii group with an increased risk of allergic rhinitis (IVW Odds Ratio [OR = 1. 26] [1. 04, 1. 53], p-value = 0. 01645). In addition, the genus Fusicatenibacter (IVW OR = 1. 20 [1. 02, 1. 41], p-value = 0 V体育ios版. 02868) was causally associated with an increased risk of vasomotor rhinitis. .

Conclusion: Gut microbiota belonging to different genera exert different effects on allergic rhinitis and vasomotor rhinitis, including reducing the risk of rhinitis, and increasing the risk of rhinitis VSports最新版本. New insights into the mechanisms of underlying gut microbiota-associated rhinitis are provided. .

Level of evidence: Level 5 V体育平台登录. .