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Comparative Study
. 2024 May-Jun;90(3):101399.
doi: 10.1016/j.bjorl.2024.101399. Epub 2024 Feb 21.

"V体育2025版" Comparison of treatment efficacy of omega-3 fish oil and montelukast in ovalbumin-protease-induced allergic rhinitis model in rats

Alper Tabaru  1 , Sahin Ogreden  2 , Salih Akyel  2 , Mehmet Faruk Oktay  3 , Kemal Uslu  3 , Funda Kaya Emre  4
Affiliations
Comparative Study

"V体育平台登录" Comparison of treatment efficacy of omega-3 fish oil and montelukast in ovalbumin-protease-induced allergic rhinitis model in rats

Alper Tabaru et al. Braz J Otorhinolaryngol. 2024 May-Jun.

Abstract (VSports注册入口)

Objectives: Montelukast is a well-known leukotriene receptor antagonist commonly used in treating allergic rhinitis and asthma. Omega-3 fatty acid is also known as an antiallergic and immunomodulator molecule. This study aimed to elucidate the efficacy of systemic montelukast and omega-3 fatty acid treatment in allergic rhinitis models in Wistar Hannover rats. VSports手机版.

Methods: This research was conducted on 28 healthy Wistar Hannover rats weighing 250-350 g. After establishing the allergic rhinitis model, nasal symptoms were observed and scored, and the nasal mucosa of all rats was investigated histologically. Light microscopy was utilized to evaluate the degree of ciliary loss, goblet cell hyperplasia, vascular congestion, vascular proliferation, inflammatory cell infiltration, eosinophil infiltration, and hypertrophy in chondrocytes. V体育安卓版.

Results: As a result of the analysis of the data obtained from the study, it was determined that typical allergic rhinitis symptoms such as nasal scratching and sneezing were significantly reduced in the rats in the montelukast and omega-3 treated group, and these symptoms did not increase after repeated intranasal OVA-protease applications. Histological examinations after fish oil treatment did not reveal typical inflammatory changes in allergic rhinitis. None of the rats in the montelukast and omega-3 groups had any increase in goblet cells, whereas 14. 3% of the rats in the control group and 28. 6% of the rats in the allergic rhinitis group had mild increase. Last but not least, 71. 4% of rats in the allergic rhinitis group had a moderate increase. The difference between the groups was statistically significant (p < 0. 001). V体育ios版.

Conclusion: Regarding the outcomes of this research, it was observed that w-3 fatty acids had antiallergic effects, both histopathological and clinical, in the allergic rhinitis model. We believe that further randomized controlled trials incorporating larger cohorts are warranted to verify the use of omega-3 fatty acids in treating allergic rhinitis. The level of evidence of this article is Level 2 VSports最新版本. .

Keywords: Allergic rhinitis; Fish oil; Montelukast; Nasal symptoms; Omega-3. V体育平台登录.

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Figures

Fig. 1
Fig. 1
(A) Goblet cell hyperplasia, increased inflammation, loss of cilia, and increased eosinophils in Allergic Rhinit model (HE × 40). (B) Congestion and increased vascularisation in Allergic Rhinit model (HE × 40). (C) Chondrosithipertrophy in Allergic Rhinit model (HE × 40).
Fig. 2
Fig. 2
(A) The section in which the cilia are clearly observed, and there is no inflammation and eosinophil increase in the montelukast treatment group (HE × 40) and (B) the section where inflammation is not observed, cilia are preserved, and goblet cell hyperplasia is not observed in the omega-3 fatty acid oil treatment group (HE × 40).
See this image and copyright information in PMC

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