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Review
. 2022 Sep 20;14(19):3889.
doi: 10.3390/nu14193889.

Emerging Role of Nicotinamide Riboside in Health and Diseases (V体育平台登录)

Chiranjeev Sharma  1 , Dickson Donu  1 , Yana Cen  1   2
Affiliations
Review

Emerging Role of Nicotinamide Riboside in Health and Diseases

Chiranjeev Sharma et al. Nutrients. .

Abstract

Among all the NAD+ precursors, nicotinamide riboside (NR) has gained the most attention as a potent NAD+-enhancement agent. This recently discovered vitamin, B3, has demonstrated excellent safety and efficacy profiles and is orally bioavailable in humans. Boosting intracellular NAD+ concentrations using NR has been shown to provide protective effects against a broad spectrum of pathological conditions, such as neurodegenerative diseases, diabetes, and hearing loss. In this review, an integrated overview of NR research will be presented. The role NR plays in the NAD+ biosynthetic pathway will be introduced, followed by a discussion on the synthesis of NR using chemical and enzymatic approaches. NR's effects on regulating normal physiology and pathophysiology will also be presented, focusing on the studies published in the last five years. VSports手机版.

Keywords: COVID-19; dietary supplements; health; nicotinamide riboside; vitamin B3. V体育安卓版.

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VSports在线直播 - Conflict of interest statement

The authors declare no conflict of interest.

VSports最新版本 - Figures

Figure 1
Figure 1
NAD+ biosynthetic pathways in mammalian cells. NA: nicotinic acid; NAM: nicotinamide; NR: nicotinamide riboside; NMN: nicotinamide mononucleotide; NaMN: nicotinic acid mononucleotide; NaAD: nicotinic acid adenine dinucleotide; NRH: reduced nicotinamide riboside; NMNH: reduced nicotinamide mononucleotide; QPRTase: quinolinate phosphoribosyltransferase; NMNAT: nicotinamide mononucelotide adenylyltransferase; NaPRTase: nicotinic acid phosphoribosyl transferase; NAMPT: nicotinamide phosphoribosyl transferase; NRK: nicotinamide riboside kinase; PNP: purine nucleoside phosphorylase; AK: adenosine kinase; NQO2: NRH: quinone oxidoreductase 2.
Figure 2
Figure 2
NR synthesis: glycosylation of NAM and acetylated-D-ribofuranose. (A) Synthetic scheme of β-NR triflate developed by Kirihata et al. [53]; (B) Neighboring group participation leads to the formation of β-NR as the major anomer.
Figure 3
Figure 3
Synthetic scheme of β-NR triflate developed by Sauve et al. [39,55].
Figure 4
Figure 4
Schematic representation of the chemo-enzymatic synthesis of 13C, 18O-NR.
See this image and copyright information in PMC

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