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. 2022 Sep 9:9:962787.
doi: 10.3389/fnut.2022.962787. eCollection 2022.

V体育平台登录 - The causal association of polyunsaturated fatty acids with allergic disease: A two-sample Mendelian randomization study

Yajia Li  1   2 , Qiangxiang Li  2   3   4 , Ziqin Cao  2   5 , Jianhuang Wu  2   5
Affiliations

The causal association of polyunsaturated fatty acids with allergic disease: A two-sample Mendelian randomization study

Yajia Li et al. Front Nutr. .

Abstract

Objectives: Previous studies have reported a potential association of polyunsaturated fatty acids (PUFAs) levels with allergic disease risk and the possible benefit of PUFAs supplementation on allergic disease prevention VSports手机版. This study was performed to estimate the genetic association between PUFAs and allergic diseases using the method of both univariable and multivariable two-sample Mendelian randomization (MR). .

Methods: As indicators of the PUFAs levels, we included the omega-3, omega-6, docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), linoleic acid (LA), and the ratio of omega-6 to omega-3 (omega-6:3). Summarized statistics of genome-wide association studies (GWASs) for these PUFAs were obtained from the United Kingdom Biobank and the Twins United Kingdom cohort. Genetic data relating to allergic diseases, including atopic dermatitis (AD), allergic rhinitis (AR), allergic conjunctivitis (AC), allergic urticaria (AU) and asthma, were accessed from the FinnGen biobank analysis. Odds ratios and 95% CIs were used to express the impact. V体育安卓版.

Results: The MR results denoted a genetic association between the genetically determined increase in omega-3 levels and the decreased risk of some allergic diseases including AD (OR: 0. 863; 95% CI: 0. 785 to 0. 949; p = 3. 86E-03), AC (OR:0. 720; 95% CI: 0. 547 to 0. 947; p = 1. 87E-02) and AU (OR:0. 821; 95% CI: 0. 684 to 0. 985; p = 3. 42E-02), while omega-6 and DHA level was only found to have negatively correlation with risk of AC with ORs of 0 V体育ios版. 655 (95% CI: 0. 445 to 0. 964; p = 3. 18E-02) and 0. 671 (95% CI 0. 490 to 0. 918; p = 1. 25E-02), respectively. Omega-6:3 were causally significantly associated with the increased risk of AD (OR:1. 171; 95% CI: 1. 045 to 1. 312; p = 6. 46E-03) and AC (IVW: OR:1. 341; 95% CI: 1. 032 to 1. 743; p = 2. 83E-02). After adjustment of age, economic level, BMI, smoking and alcohol behaviors in the multivariable MR analysis, a direct causal protective effect of omega-3 on AD and AC, as well as a direct causal association between DHA and AD were observed. Omega-6:3 was also found to be directly associated with an increased risk of AD and AC. No association was found of EPA or LA with allergic diseases. .

Conclusion: Higher PUFA concentrations (omega-3, omega-6, DHA) and lower omega-6:3 ratios were genetically associated with a lower risk of some allergic diseases VSports最新版本. .

Keywords: Mendelian randomization study; allergic diseases; omega-3; omega-6; polyunsaturated fatty acids V体育平台登录. .

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The overview flowchart of hypothesis and schematic design (A) Mendelian randomization key hypothesis Diagram. SNPs associated with PUFAs levels/ratios were used as the genetic instruments for investigating the causal effect of PUFA on allergic diseases. Line with arrows indicates that the genetic instruments (SNPs) are associated with the exposure and can only affect the outcome via the exposure. Dashed lines indicate that the genetic instruments (SNPs) are independent of confounders between the results. (B) Schematic design for the mendelian randomization analysis.
FIGURE 2
FIGURE 2
The forest plot of univariable Mendelian randomization analyses exploring associations between omega-3 fatty acids and risk of allergic diseases using different Mendelian randomization statistical models OR: odds ratio; CIs: confidence intervals.
FIGURE 3
FIGURE 3
The forest plot of univariable Mendelian randomization analyses exploring associations between omega-6 fatty acids and risk of allergic diseases using different Mendelian randomization statistical models OR: odds ratio; CIs: confidence intervals.
FIGURE 4
FIGURE 4
The forest plot of univariable Mendelian randomization analyses exploring associations between docosahexaenoic acid and allergic diseases risk using different Mendelian randomization statistical models OR: odds ratio; CIs: confidence intervals.
FIGURE 5
FIGURE 5
The forest plot of univariable Mendelian randomization analyses exploring associations between ratio of omega-6 fatty acids and omega-3 fatty acids to allergic diseases risk using different Mendelian randomization statistical models OR: odds ratio; CIs: confidence intervals.
FIGURE 6
FIGURE 6
The forest plot of the multivariable Mendelian randomization exploring the associations between genetically determined polyunsaturated fatty acids and allergic diseases adjusted for confounding traits (body mass index, smoking, alcohol intake, age, and income level) OR: odds ratio; CIs: confidence intervals; Omega-3: omega-3 fatty acids; Omega-6: omega-6 fatty acids; DHA: docosahexaenoic acid; LA: linoleic acid; EPA: eicosapentaenoic acid; RO63: ratio of omega-6 fatty acids to omega-3 fatty acids; AD: atopic dermatitis; AC: Atopic conjunctivitis; AR: Allergic rhinitis; AU: Allergic urticaria.
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References (VSports)

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