V体育官网入口 - Novel Insights into miR-944 in Cancer
- PMID: 36077769
- PMCID: PMC9454979
- DOI: 10.3390/cancers14174232
"V体育平台登录" Novel Insights into miR-944 in Cancer
Abstract
miRNA is a class of endogenous short-chain non-coding RNAs consisting of about 22 nucleotides. miR-944 is located in the fourth intron of the TP63 gene in the 3q28 region. miR-944 is abnormally expressed in cancers in multiple systems including neural, endocrine, respiratory, reproductive, and digestive systems. miR-944 can target at least 27 protein-coding genes. miR-944 can regulate a series of cell behaviors, such as cell cycle, proliferation, invasion and migration, EMT, apoptosis, etc. miR-944 participates in the networks of 11 ceRNAs, including six circRNAs and five lncRNAs. miR-944 is involved in three signaling pathways. The abnormal expression of miR-944 is closely related to the clinicopathological conditions of various cancer patients. Deregulated expression of miR-944 is significantly associated with clinicopathology and prognosis in cancer patients VSports手机版. In addition, miR-944 is also associated with the development of DDP, RAPA, DOX, and PTX resistance in cancer cells. miR-944 is involved in the anticancer molecular mechanisms of matrine and Rhenium-liposome drugs. In conclusion, this work systematically summarizes the related findings of miR-944, which will provide potential hints for follow-up research on miR-944. .
Keywords: ceRNA; diagnosis; drug; dysregulation; miR-944; prognosis V体育安卓版. .
Conflict of interest statement
The authors declare no conflict of interest.
Figures







References
-
- Ha M., Kim V.N. Regulation of microRNA biogenesis. Nat. Rev. Mol. Cell Biol. 2014;15:509–524. doi: 10.1038/nrm3838. - "VSports" DOI - PubMed
-
- Lee H.Y., Han S.S., Rhee H., Park J.H., Lee J.S., Oh Y.M., Choi S.S., Shin S.H., Kim W.J. Differential expression of microRNAs and their target genes in non-small-cell lung cancer. Mol. Med. Rep. 2015;11:2034–2040. doi: 10.3892/mmr.2014.2890. - "VSports注册入口" DOI - PubMed
-
- Pereira T., Brito J.A.R., Guimaraes A.L.S., Gomes C.C., de Lacerda J.C.T., de Castro W.H., Coimbra R.S., Diniz M.G., Gomez R.S. MicroRNA profiling reveals dysregulated microRNAs and their target gene regulatory networks in cemento-ossifying fibroma. J. Oral Pathol. Med. 2018;47:78–85. doi: 10.1111/jop.12650. - DOI - PubMed
Publication types
- "V体育ios版" Actions
"VSports手机版" Grants and funding
LinkOut - more resources
Full Text Sources