Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The VSports app下载. gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

Meta-Analysis
. 2022 Jul 28;17(7):e0271038.
doi: 10.1371/journal.pone.0271038. eCollection 2022.

Metformin and thyroid carcinoma incidence and prognosis: A systematic review and meta-analysis

Affiliations
Meta-Analysis

"V体育安卓版" Metformin and thyroid carcinoma incidence and prognosis: A systematic review and meta-analysis

Zikun Wang et al. PLoS One. .

Abstract

Metformin has been suggested to reduce thyroid cancer incidence and to improve thyroid cancer prognosis. We aimed to evaluate the associations between metformin and thyroid cancer incidence and prognosis (metastasis/recurrence/progression-free survival). Cochrane Library, PubMed, ClinicalTrials. gov, and U. S. National Library of Medicine Clinical Trials were searched through the end of December 2021. Data were collected from original observational studies or clinical trials on the incidence or prognosis of thyroid carcinoma outcomes in type 2 diabetes mellitus (T2DM) patients with and without metformin use. Risk of bias in non-randomized studies of interventions (ROBINS-I) tool and Grading of Recommendations, and Assessment, Development and Evaluations (GRADE) approach were used to evaluate the risk of bias and quality of the body of evidence, respectively. In general, 4 studies were related to the thyroid cancer incidence, including 1,705,123 participants metformin users and non-users and yielding a total of 3,238 thyroid cancer events; 3 studies reported the prognosis of thyroid carcinoma based on a total of 4,972 individuals with primary thyroid carcinoma and comorbid type 2 diabetes, and the number of thyroid cancer prognosis cases ranged from 3 to 79. The overall risk of bias of the included studies ranged from moderate to serious. In the random-effects model, the summary relative risk (SRR) for thyroid cancer incidence was 0 VSports手机版. 743 (95% CI: 0. 453-1. 220; I2 = 88. 7%, low certainty) comparing metformin users to non-users; and SRR for the prognosis of thyroid cancer was 0. 504 (95% CI: 0. 178-1. 430; I2 = 57. 5%, low certainty). Non-statistically significant negative associations between metformin use and incidence and prognosis of thyroid cancer were found in the current analysis, although the quantity and quality of the evidence were limited. Futher investigation is needed to evaluate the clinical benefits of metformin on thyroid cancer prevention and treatments. .

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flowchart of the study selection process.
Fig 2
Fig 2. Forest plot of associations between metformin, incidence and prognosis of thyroid cancera,b.
a: Black boxes denote point estimates for HRs and ORs, and horizontal lines represent 95% CIs. Black diamonds, Summary risk ratio (SRR) estimates. No association under the null hypothesis (risk estimate equal to 1.00) was represented by the vertical dotted line. b:Incidence studies: [29, 30, 33, 34]; Prognosis studies: 1) Klubo-Gwiezddzinska J et al, [35] the progression-free survival of thyroid cancer; 2) Noh Y et al, [31] the metastasis of thyroid cancer; 3) Jang EK et al, [36] the recurrence of thyroid cancer.
Fig 3
Fig 3. The risk of bias assessment for each study.

References

    1. Ahmedin Jemal RS, Kimberly D. Miller. Cancer Facts & Figures 2021: American Cancer Society.; 2021 [Available from: https://www.cancer.org/cancer/non-hodgkin-lymphoma/about/key-statistics.....
    1. Pathak KA, Leslie WD, Klonisch TC, Nason RW. The changing face of thyroid cancer in a population-based cohort. Cancer Med. 2013;2(4):537–44. doi: 10.1002/cam4.103 - DOI (V体育官网) - PMC - PubMed
    1. Kim J, Gosnell JE, Roman SA. Geographic influences in the global rise of thyroid cancer. Nat Rev Endocrinol. 2020;16(1):17–29. doi: 10.1038/s41574-019-0263-x - DOI - PubMed
    1. Zhai M, Zhang D, Long J, Gong Y, Ye F, Liu S, et al.. The global burden of thyroid cancer and its attributable risk factor in 195 countries and territories: A systematic analysis for the Global Burden of Disease Study. Cancer Med. 2021;10(13):4542–54. doi: 10.1002/cam4.3970 - DOI - PMC - PubMed
    1. Bethesda. SEER Cancer Stat Facts: Thyroid Cancer. National Cancer Institute: National Cancer Institute; 2018 [updated 2021; cited 2021. Available from: https://seer.cancer.gov/statfacts/html/thyro.html.

MeSH terms