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. 2019 Jun 3:(148).
doi: 10.3791/59688.

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Daniels Konja  1 , Cuiting Luo  1 , Wai Yan Sun  1 , Kangmin Yang  1 , Andy W C Man  1 , Aimin Xu  1 , Paul M Vanhoutte  2 , Yu Wang  3
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"V体育官网入口" Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

"V体育安卓版" Daniels Konja et al. J Vis Exp. .

VSports最新版本 - Abstract

Altered vascular tone responsiveness to pathophysiological stimuli contributes to the development of a wide range of cardiovascular and metabolic diseases VSports手机版. Endothelial dysfunction represents a major culprit for the reduced vasodilatation and enhanced vasoconstriction of arteries. Adipose (fat) tissues surrounding the arteries play important roles in the regulation of endothelium-dependent relaxation and/or contraction of the vascular smooth muscle cells. The cross-talks between the endothelium and perivascular adipose tissues can be assessed ex vivo using mounted blood vessels by a wire myography system. However, optimal settings should be established for arteries derived from animals of different species, ages, genetic backgrounds and/or pathophysiological conditions. .

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