<b dropzone="lRAjE5"></b>
"VSports手机版" Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The VSports app下载. gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

. 2018 Mar:42:262-270.
doi: 10.1016/j.jff.2017.12.057. Epub 2018 Jan 30.

Dried Plum Polyphenolic Extract Combined with Vitamin K and Potassium Restores Trabecular and Cortical Bone in Osteopenic Model of Postmenopausal Bone Loss

Jennifer L Graef  1 , Ping Ouyang  1 , Yan Wang  1 , Elizabeth Rendina-Ruedy  1 , Megan R Lerner  2 , Denver Marlow  3 , Edralin A Lucas  1 , Brenda J Smith  1
Affiliations

VSports手机版 - Dried Plum Polyphenolic Extract Combined with Vitamin K and Potassium Restores Trabecular and Cortical Bone in Osteopenic Model of Postmenopausal Bone Loss

Jennifer L Graef et al. J Funct Foods. 2018 Mar.

Abstract

Dried plum has unique anabolic effects on bone, but the responsible bioactive components have remained unclear. This study investigated components of dried plum with potential osteoprotective activity utilizing aged, osteopenic Sprague Dawley rats fed diets supplemented with a crude polyphenol extract, potassium, vitamin K or their combination. Whole body and femoral bone mineral density were restored with the polyphenol and combination treatments to a similar extent as the dried fruit. The combination treatment reversed trabecular bone loss in the spine and cortical bone in the femur mid-diaphysis in a similar manner VSports手机版. Biomarkers of bone resorption were reduced by the polyphenol and combination treatments. The polyphenol extract accounted for most of the anabolic effect of dried plum on bone. This study is the first to show the bioactive components in dried plum responsible for restoring bone in vivo. .

Keywords: aging; bone; dried plum; estrogen deficiency; polyphenols V体育安卓版. .

PubMed Disclaimer

Figures

Figure 1
Figure 1
Whole body bone mineral density (BMD) was measured at baseline, 2 months after ovariectomy but prior to beginning dietary treatment (Pre-Tx), and following 3 months of dietary treatment (Post-Tx). Bars represent the mean ± SE. Data points that do not share the same superscript letter are statistically different from each other, p < 0.05. Abbreviations: OVX, ovariectomized; Con, control diet; DP, dried plum; PP, polyphenol; K+, potassium; VitK, vitamin K; Combo, combination of PP, K+, and VitK.
Figure 2
Figure 2
Bone microarchitecture was assessed in the 4th lumbar vertebra and the femur following 3 months of dietary treatment. Three dimensional micro-computed tomography images are shown. Trabecular bone volume was assessed in the vertebra and the distal femur metaphysis (top two images). Cortical bone was assessed in the femur mid-diaphysis (bottom). Abbreviations: OVX, ovariectomized; Con, control diet; DP, dried plum; PP, polyphenol; K+, potassium; VitK, vitamin K; Combo, combination of PP, K+, and VitK.
Figure 3
Figure 3
Urinary excretion of deoxypyridinoline (DPD) was measured as an indicator of bone resorption. The animals were placed in metabolic cages and 12-hour urine samples were collected. Bars that do not share the same superscript letter are statistically different from each other, p < 0.05. Abbreviations: OVX, ovariectomized; Con, control diet; DP, dried plum; PP, polyphenol; K+, potassium; VitK, vitamin K; Combo, combination of PP, K+, and VitK.
Figure 4
Figure 4
Alterations in the relative abundance of mRNA for bone morphogenetic proteins, Bmp2 and Bmp4 in the distal femur metaphysis. Relative mRNA expression of (a) Bmp2 and (b) Bmp4 was assessed in the distal femur metaphysis following 3 months of dietary treatment. Bars represent the mean fold change ± SE. Data points that do not share the same superscript letter are statistically different from each other, p < 0.05. Abbreviations: OVX, ovariectomized; Con, control diet; DP, dried plum; PP, polyphenol; K+, potassium; VitK, vitamin K; Combo, combination of PP, K+, and VitK.
See this image and copyright information in PMC

References

    1. Almeida M, Han L, Martin-Millan M, Plotkin LI, Stewart SA, Roberson PK, Manolagas SC. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem. 2007;282(37):27285–27297. doi: 10.1074/jbc.M702810200. - DOI - PMC - PubMed
    1. Arjmandi BH, Johnson CD, Campbell SC, Hooshmand S, Chai SC, Akhter MP. Combining fructooligosaccharide and dried plum has the greatest effect on restoring bone mineral density among select functional foods and bioactive compounds. J Med Food. 2010;13(2):312–319. doi: 10.1089/jmf.2009.0068. - DOI - PubMed
    1. Arjmandi BH, Khalil DA, Lucas EA, Georgis A, Stoecker BJ, Hardin C, Wild RA. Dried plums improve indices of bone formation in postmenopausal women. J Womens Health Gend Based Med. 2002;11(1):61–68. - PubMed
    1. Arjmandi BH, Lucas E, Juma S, Soliman A, Stoecker B, Khalil D, Wang C. Dried plums prevent ovariectomy-induced bone loss in rats. JANA. 2001;4(1):50–56.
    1. Baek KH, Oh KW, Lee WY, Lee SS, Kim MK, Kwon HS, Kang MI. Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cultures. Calcif Tissue Int. 2010;87(3):226–235. doi: 10.1007/s00223-010-9393-9. - DOI - PubMed

"VSports在线直播" Grants and funding

LinkOut - more resources (VSports)