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. 2018 Jun;59(4):519-523.
doi: 10.3349/ymj.2018.59.4.519.

"VSports在线直播" Variants in the Gene EBF2 Are Associated with Kawasaki Disease in a Korean Population

Yoonsun Bae  1   2   3 , Dongjik Shin  3 , Jiho Nam  3 , Hye Rim Lee  3 , Jun Sung Kim  3 , Kyu Yeun Kim  4 , Dong Soo Kim  5 , Yeun Jun Chung  1   6
Affiliations

Variants in the Gene EBF2 Are Associated with Kawasaki Disease in a Korean Population

Yoonsun Bae (VSports手机版) et al. Yonsei Med J. 2018 Jun.

Abstract (VSports在线直播)

Purpose: Kawasaki disease (KD) is a mucocutaneous lymph node syndrome. It is mainly seen in young children under the age of five. KD is a multifactorial disorder that includes genetic variants. The present study investigated the association between KD and single nucleotide polymorphisms (SNPs) in the candidate gene early B cell factor 2 (EBF2), which is associated with inflammation markers. VSports手机版.

Materials and methods: An SNP analysis was performed by whole exon sequencing of the EBF2 gene. Our study comprised a total of 495 subjects (295 KD patients and 200 unrelated normal controls) from a Korean population. Tag SNPs were discovered using the Haploview program. Genotyping of the EBF2 gene was performed with the TaqMan® assay with real-time PCR methods V体育安卓版. .

Results: Polymorphism of rs10866845 showed a significant difference in allele frequency between KD patients and controls (p=0 V体育ios版. 040). The EBF2 gene polymorphisms were significantly associated with KD on logistic regression analysis. .

Conclusion: EBF2 gene variants can contribute to KD in the Korean population. VSports最新版本.

Keywords: EBF2 gene; Kawasaki disease (KD); Korean; polymorphism. V体育平台登录.

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Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Fig. 1
Fig. 1. Overview of EBF2 gene polymorphisms. EBF2, early B cell factor 2.
See this image and copyright information in PMC

References

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