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Clinical Trial
. 2017 Nov;16(11):1155-1161.
doi: 10.1038/nmat4997. Epub 2017 Oct 9.

Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma

Rui-Hua Xu  1 , Wei Wei  1   2 , Michal Krawczyk  2 , Wenqiu Wang  2 , Huiyan Luo  1   2 , Ken Flagg  2 , Shaohua Yi  2 , William Shi  2 , Qingli Quan  3 , Kang Li  3 , Lianghong Zheng  4 , Heng Zhang  5 , Bennett A Caughey  2 , Qi Zhao  1 , Jiayi Hou  2 , Runze Zhang  2 , Yanxin Xu  3 , Huimin Cai  3   4 , Gen Li  3   4 , Rui Hou  4 , Zheng Zhong  2 , Danni Lin  2 , Xin Fu  2 , Jie Zhu  2 , Yaou Duan  2 , Meixing Yu  3 , Binwu Ying  6 , Wengeng Zhang  3 , Juan Wang  7 , Edward Zhang  2 , Charlotte Zhang  2 , Oulan Li  2 , Rongping Guo  1 , Hannah Carter  2 , Jian-Kang Zhu  5 , Xiaoke Hao  7 , Kang Zhang  2   3   8
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Clinical Trial

Circulating tumour DNA methylation markers for diagnosis and prognosis of hepatocellular carcinoma

Rui-Hua Xu et al. Nat Mater. 2017 Nov.

Abstract

An effective blood-based method for the diagnosis and prognosis of hepatocellular carcinoma (HCC) has not yet been developed. Circulating tumour DNA (ctDNA) carrying cancer-specific genetic and epigenetic aberrations may enable a noninvasive 'liquid biopsy' for diagnosis and monitoring of cancer. Here, we identified an HCC-specific methylation marker panel by comparing HCC tissue and normal blood leukocytes and showed that methylation profiles of HCC tumour DNA and matched plasma ctDNA are highly correlated. Using cfDNA samples from a large cohort of 1,098 HCC patients and 835 normal controls, we constructed a diagnostic prediction model that showed high diagnostic specificity and sensitivity (P < 0 VSports手机版. 001) and was highly correlated with tumour burden, treatment response, and stage. Additionally, we constructed a prognostic prediction model that effectively predicted prognosis and survival (P < 0. 001). Together, these findings demonstrate in a large clinical cohort the utility of ctDNA methylation markers in the diagnosis, surveillance, and prognosis of HCC. .

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