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Review
. 2017 Aug 1;47(8):671-677.
doi: 10.1093/jjco/hyx059.

"V体育官网" Current approach and future perspective for ductal carcinoma in situ of the breast

Affiliations
Review

Current approach and future perspective for ductal carcinoma in situ of the breast

Chizuko Kanbayashi et al. Jpn J Clin Oncol. .

V体育平台登录 - Abstract

Ductal carcinoma in situ (DCIS) has a good prognosis with the current treatment approach, with a 10-year breast cancer-specific survival rate of 97-98%. In ductal carcinoma in situ without micrometastasis, surgery and postoperative adjuvant therapy significantly improve local control, however it has been reported that the selection of the surgical procedure and adjuvant therapy does not influence breast cancer death. On the other hand, owing to widespread mammography screening, the frequency of early breast cancer detection has increased. In early breast cancer, increased incidence of DCIS is remarkable. However, there is not enough reduction of advanced cancer to match it. Problems with overdiagnosis are now being discussed all over the world. It has been reported that surgery for low-grade ductal carcinoma in situ does not contribute to breast cancer-specific survival. However, it is currently impossible to reliably identify a population that does not progress to invasive cancer even without treatment. Recently, a non-surgery clinical trial for low-risk ductal carcinoma in situ was started. There is a possibility of achieving individualized treatment for ductal carcinoma in situ with less treatment intervention, without compromising the good prognosis obtained with the current treatment approach. This review presents an overview of the current treatment approaches, problems with overdiagnosis and potential future management strategies for ductal carcinoma in situ of the breast VSports手机版. .

Keywords: breast cancer; clinical trial; ductal carcinoma in situ; low grade DCIS; overtreatment V体育安卓版. .

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Figures

Figure 1.
Figure 1.
LORIS trial.
Figure 2.
Figure 2.
JCOG 1505 (LORETTA trial).

References

    1. Wapnir IL, Dignam JJ, Fisher B, et al. . Long-term outcomes of invasive ipsilateral breast tumor recurrences after lumpectomy in NSABP B-17 and B-24 randomized clinical trials for dshis. J Natl Cancer Inst 2011;103:478–88. - V体育2025版 - PMC - PubMed
    1. Kerlikowske K. Epidemiology of ductal carcinoma in situ. J Natl Cancer Inst Monogr 2010;41:139–41. - VSports手机版 - PMC - PubMed
    1. Projected cancer incidence in Japan 2016: Center for Cancer Control and Information Service, National Cancer Center http://ganjoho.jp/reg_stat/statistics/stat/short_pred.html (V体育官网入口)
    1. Stuart KE, Houssami N, Taylor R, Hayen A, Boyages J. Long-term outcomes of ductal carcinoma in situ of the breast: a systematic review, meta-analysis and meta-regression analysis. BMC Cancer 2015;15:890. - PMC - PubMed
    1. Erbas B, Provenzano E, Armes J, Gertig D. The natural history of ductal carcinoma in situ of the breast: a review. Breast Cancer Res Treat 2006;97:135–44. - PubMed

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