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. 2017 Feb 2;12(2):e0171502.
doi: 10.1371/journal.pone.0171502. eCollection 2017.

VSports手机版 - Prevalence and determinants of non-alcoholic fatty liver disease in lifelines: A large Dutch population cohort

Eline H van den Berg  1 , Marzyeh Amini  2 , Tim C M A Schreuder  1 , Robin P F Dullaart  3 , Klaas Nico Faber  1 , Behrooz Z Alizadeh  1   2 , Hans Blokzijl  1
Affiliations

Prevalence and determinants of non-alcoholic fatty liver disease in lifelines: A large Dutch population cohort

Eline H van den Berg et al. PLoS One. .

Abstract

Background & aims: Non-alcoholic fatty liver disease is an increasing health issue that develops rather unnoticed with obesity, type 2 diabetes mellitus and metabolic syndrome. We investigated prevalence, determinants and associated metabolic abnormalities of non-alcoholic fatty liver disease in the largest population-based cohort to date. VSports手机版.

Methods: Biochemical characteristics, type 2 diabetes mellitus and metabolic syndrome were determined in the Lifelines Cohort Study (N = 167,729), a population-based cohort in the North of the Netherlands. Non-alcoholic fatty liver disease was defined as Fatty Liver Index (FLI)≥60. Exclusion criteria were age <18 years, immigrants, missing data to assess FLI and metabolic syndrome, excessive alcohol use, previous-diagnosed hepatitis or cirrhosis and non-fasting blood sampling V体育安卓版. .

Results: Out of 37,496 included participants (median age 44 years, 62. 1% female), 8,259 (22. 0%) had a FLI≥60. Individuals with a FLI≥60 were more often male, older, obese, had higher levels of hemoglobinA1c, fasting glucose, liver enzymes, total cholesterol, low-density lipoprotein cholesterol, triglycerides, c-reactive protein and leucocytes and lower high-density lipoprotein cholesterol (all P<0. 0001). Participants with a FLI≥60 showed higher prevalence of type 2 diabetes mellitus (9. 3% vs. 1. 4%), metabolic syndrome (54. 2% vs. 6. 2%), impaired renal function (20. 1% vs. 8. 7%) and cardiovascular disease (4. 6% vs. 1. 6%) (all P<0. 0001). Multivariable logistic analysis showed that smoking, hemoglobin, leucocytes, c-reactive protein, platelets, alanine aminotransferase, alkaline phosphatase, albumin, impaired renal function (OR 1. 27, 95%CI 1. 15-1. 41), metabolic syndrome (OR 11. 89, 95%CI 11. 03-12. 82) and its individual components hyperglycemia (OR 2. 53, 95%CI 2. 34-2. 72), hypertension (OR 1. 89, 95%CI 1. 77-2. 01) and reduced high-density lipoprotein cholesterol (OR 3. 44, 95%CI 3. 22-3. 68) were independently associated with suspected non-alcoholic fatty liver disease (all P<0. 0001) V体育ios版. .

Conclusion: Twenty-two percent (22. 0%) of the population in the North of the Netherlands is suspected to suffer from non-alcoholic fatty liver disease, coinciding with a significant increased risk of type 2 diabetes mellitus, metabolic syndrome, cardiovascular disease and impaired renal function. VSports最新版本.

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Conflict of interest statement (VSports手机版)

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow chart of the study population.
See this image and copyright information in PMC

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