Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official VSports app下载. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

Review
. 2017 Jan 26;129(4):424-447.
doi: 10.1182/blood-2016-08-733196. Epub 2016 Nov 28.

VSports app下载 - Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

Hartmut Döhner  1 , Elihu Estey  2 , David Grimwade  3 , Sergio Amadori  4 , Frederick R Appelbaum  2 , Thomas Büchner  5 , Hervé Dombret  6 , Benjamin L Ebert  7 , Pierre Fenaux  8 , Richard A Larson  9 , Ross L Levine  10 , Francesco Lo-Coco  4 , Tomoki Naoe  11 , Dietger Niederwieser  12 , Gert J Ossenkoppele  13 , Miguel Sanz  14 , Jorge Sierra  15 , Martin S Tallman  10 , Hwei-Fang Tien  16 , Andrew H Wei  17   18 , Bob Löwenberg  19 , Clara D Bloomfield  20
Affiliations
Review

VSports手机版 - Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

Hartmut Döhner et al. Blood. .

Abstract

The first edition of the European LeukemiaNet (ELN) recommendations for diagnosis and management of acute myeloid leukemia (AML) in adults, published in 2010, has found broad acceptance by physicians and investigators caring for patients with AML. Recent advances, for example, in the discovery of the genomic landscape of the disease, in the development of assays for genetic testing and for detecting minimal residual disease (MRD), as well as in the development of novel antileukemic agents, prompted an international panel to provide updated evidence- and expert opinion-based recommendations VSports手机版. The recommendations include a revised version of the ELN genetic categories, a proposal for a response category based on MRD status, and criteria for progressive disease. .

PubMed Disclaimer

VSports手机版 - Figures

Figure 1.
Figure 1.
Molecular classes of AML and concurrent gene mutations in adult patients up to the age of ∼65 years. Class definition is based on the study by Papaemmanuil et al. For each AML class denoted in the pie chart, frequent co-occurring mutations are shown in the respective boxes. Data on the frequency of genetic lesions are compiled from the databases of the British Medical Research Council (MRC), the German-Austrian AML Study Group (AMLSG), and from selected studies.,,, a indicates cohesin genes including RAD21 (∼10%), SMC1A (∼5%), and SMC3 (∼5%); b, inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11; c, inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2,MECOM(EVI1); and d, TP53 mutations are found in ∼45%, and complex karyotypes in ∼70% of this class. The structure of the pie chart is adapted from Grimwade et al, generated by Adam Ivey (King’s College London, London, United Kingdom).
See this image and copyright information in PMC

References

    1. Döhner H, Estey EH, Amadori S, et al. ; European LeukemiaNet. Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet. Blood. 2010;115(3):453-474. - PubMed
    1. Döhner H, Weisdorf DJ, Bloomfield CD. Acute myeloid leukemia. N Engl J Med. 2015;373(12):1136-1152. - PubMed (V体育ios版)
    1. Arber DA, Orazi A, Hasserjian R, et al. . The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127(20):2391-2405. - PubMed
    1. Arber DA, Vardiman JW, Brunning RD, et al. . Acute myeloid leukaemia with recurrent genetic abnormalities. In: Swerdlow S, Campo E, Harris NL, et al, eds. World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. Update to 4th Edition. Lyon, France: World Health Organization. In press.
    1. Sanz MA, Grimwade D, Tallman MS, et al. . Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood. 2009;113(9):1875-1891. - PubMed

MeSH terms

Substances