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Review
. 2016 Jan 1;76(1):10-7.
doi: 10.1158/0008-5472.CAN-15-1382. Epub 2015 Dec 15.

It's Totally Tubular....Riding The New Wave of Ovarian Cancer Research

Ruth Perets  1 , Ronny Drapkin  2
Affiliations
Review

"V体育安卓版" It's Totally Tubular....Riding The New Wave of Ovarian Cancer Research

Ruth Perets et al. Cancer Res. .

Abstract (VSports app下载)

Hereditary breast and ovarian cancer syndrome carries significant mortality for young women if effective preventive and screening measures are not taken. Preventive salpingo-oophorectomy is currently the only method known to reduce the risk of ovarian cancer-related death VSports手机版. Histopathological analyses of these surgical specimens indicate that a high proportion of ovarian cancers in women at high risk and in the general population arise from the fallopian tube. This paradigm shift concerning the cell of origin for the most common subtype of ovarian cancer, high-grade serous carcinoma, has sparked a major effort within the research community to develop new and robust model systems to study the fallopian tube epithelium as the cell of origin of "ovarian" cancer. In this review, evidence supporting the fallopian tube as the origin of ovarian cancer is presented as are novel experimental model systems for studying the fallopian tube epithelium in high-risk women as well as in the general population. This review also addresses the clinical implications of the newly proposed cell of origin, the clinical questions that arise, and novel strategies for ovarian cancer prevention. .

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Figures

Figure 1
Figure 1. Modeling high-grade serous ovarian carcinoma from the fallopian tube
Top panel. Histological images and p53 immunostaining of normal fallopian tube epithelium and the p53 signature and STIC tubal lesions. Bottom panel. The Cancer Genome Atlas defined the genetic alterations in high-grade serous ovarian carcinoma. Animal models can be divided into two broad classes: PDX and GEM models. PDX models involve transplantation of a human tumor into an immunocompromised animal (nude or NSG mice). GEM models incorporate the relevant human genetic aberrations into an intact animal engineered to express the relevant alterations.
See this image and copyright information in PMC

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