Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil VSports app下载. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

Review
. 2016 Jan;16(1):35-42.
doi: 10.1038/nrc.2015.4. Epub 2015 Dec 15.

DNA repair, genome stability and cancer: a historical perspective

Penny A Jeggo  1 , Laurence H Pearl  1 , Antony M Carr  1
Affiliations
Review

DNA repair, genome stability and cancer: a historical perspective

Penny A Jeggo et al. Nat Rev Cancer. 2016 Jan.

Abstract

The multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance. However, the broader role of the DNA damage response (DDR) emerged more slowly VSports手机版. In this Timeline article, we reflect on how our understanding of the steps leading to cancer developed, focusing on the role of the DDR. We also consider how our current knowledge can be exploited for cancer therapy. .

PubMed Disclaimer

V体育ios版 - References

    1. Nat Genet. 1997 Sep;17(1):100-3 - PubMed
    1. Nat Med. 2013 Nov;19(11):1381-8 - PubMed
    1. Science. 2015 May 22;348(6237):880-6 - PubMed
    1. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9974-9 - PubMed (VSports手机版)
    1. Bull Soc Liban Hist Med. 1993;(4):98-101 - PubMed

Publication types (V体育安卓版)

LinkOut - more resources