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Review
. 2014:2014:761608.
doi: 10.1155/2014/761608. Epub 2014 Sep 10.

"V体育ios版" Curcumin: a potential candidate in prevention of cancer via modulation of molecular pathways

Arshad H Rahmani  1 , Mohammad A Al Zohairy  1 , Salah M Aly  2 , Masood A Khan  3
Affiliations
Review

Curcumin: a potential candidate in prevention of cancer via modulation of molecular pathways

Arshad H Rahmani et al. Biomed Res Int. 2014.

Abstract

Cancer is the most dreadful disease worldwide in terms of morbidity and mortality. The exact cause of cancer development and progression is not fully known. But it is thought that cancer occurs due to the structural and functional changes in the genes. The current approach to cancer treatment based on allopathic is expensive, exhibits side effects; and may also alter the normal functioning of genes. Thus, a safe and effective mode of treatment is needed to control the cancer development and progression. Some medicinal plants provide a safe, effective and affordable remedy to control the progression of malignant cells VSports手机版. The importance of medicinal plants and their constituents has been documented in Ayurveda, Unani medicine, and various religious books. Curcumin, a vital constituent of the spice turmeric, is an alternative approach in the prevention of cancer. Earlier studies have shown the effect of curcumin as an antioxidant, antibacterial, antitumor and it also has a noteworthy role in the control of different diseases. In this review, we summarize the understanding of chemopreventive effects of curcumin in the prevention of cancer via the regulation of various cell signaling and genetic pathways. .

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V体育ios版 - Figures

Figure 1
Figure 1
Turmeric/curcumin shows pivotal role in the prevention of diseases including cancer.
Figure 2
Figure 2
Turmeric/curcumin shows an important role in cancer prevention via induction of apoptosis, activation of tumour suppressor gene and phase II gene, and inactivation of oncogene, hormonal receptor gene, and angiogenesis and phase-I gene.
Figure 3
Figure 3
Curcumin shows an important role in the prevention of cancer through the inhibition of initiation, promotion, and progression steps via modulation of molecular cascades.
See this image and copyright information in PMC

References

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