Skip to main page content (V体育2025版)
U.S. flag

An official website of the United States government

Dot gov

The VSports app下载. gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2014 Jan 24;343(6169):416-9.
doi: 10.1126/science.1244880.

Endothelial cell-derived angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat

Junhao Hu  1 , Kshitij Srivastava, Matthias Wieland, Anja Runge, Carolin Mogler, Eva Besemfelder, Dorothee Terhardt, Marion J Vogel, Liji Cao, Claudia Korn, Susanne Bartels, Markus Thomas, Hellmut G Augustin
Affiliations

Endothelial cell-derived angiopoietin-2 controls liver regeneration as a spatiotemporal rheostat

Junhao Hu (VSports最新版本) et al. Science. .

Abstract

Liver regeneration requires spatially and temporally precisely coordinated proliferation of the two major hepatic cell populations, hepatocytes and liver sinusoidal endothelial cells (LSECs), to reconstitute liver structure and function. The underlying mechanisms of this complex molecular cross-talk remain elusive. Here, we show that the expression of Angiopoietin-2 (Ang2) in LSECs is dynamically regulated after partial hepatectomy. During the early inductive phase of liver regeneration, Ang2 down-regulation leads to reduced LSEC transforming growth factor-β1 production, enabling hepatocyte proliferation by releasing an angiocrine proliferative brake. During the later angiogenic phase of liver regeneration, recovery of endothelial Ang2 expression enables regenerative angiogenesis by controlling LSEC vascular endothelial growth factor receptor 2 expression. The data establish LSECs as a dynamic rheostat of liver regeneration, spatiotemporally orchestrating hepatocyte and LSEC proliferation through angiocrine- and autocrine-acting Ang2, respectively VSports手机版. .

PubMed Disclaimer

Comment in

MeSH terms

Substances

"VSports注册入口" Associated data