Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

. 2013 Jul;36(1):115-24.
doi: 10.1016/j.etap.2013.03.012. Epub 2013 Mar 30.

Combination treatment with platycodin D and osthole inhibits cell proliferation and invasion in mammary carcinoma cell lines (VSports)

Yiyi Ye  1 , Xianghui Han, Baofeng Guo, Zhenping Sun, Sheng Liu
Affiliations

Combination treatment with platycodin D and osthole inhibits cell proliferation and invasion in mammary carcinoma cell lines

V体育官网入口 - Yiyi Ye et al. Environ Toxicol Pharmacol. 2013 Jul.

Abstract

In this study, two invasive mammary carcinoma cells (MDA-MB-231 and 4T1) were utilized to evaluate the inhibitory activities of platycodin D, osthole, and the two in combination. The anti-proliferative effect was tested using the MTT and BrdU assay, and the combination of 15μM osthole and 75μM platycodin D was used for subsequent analyses. The anti-invasive effect was evaluated by the transwell assay. The results showed that the combination treatment reduced both cell proliferation and invasion. Western blot and real-time PCR revealed that the platycodin D-osthole combination significantly decreased TβRII, Smad2, Smad3 and Smad4 gene or protein expressions, as well as effectively blocked TGF-β-induced phosphorylation of Smad2 and Smad3 VSports手机版. Thus, this study demonstrates that the anti-cancer effects of the platycodin D-osthole combination in breast cancer cells involve proliferation inhibition and invasion blockade, both of which may be mediated by perturbations in the TGF-β/Smads pathway. .

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources (V体育平台登录)