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. 2012 Nov 26;55(22):9531-40.
doi: 10.1021/jm301217c. Epub 2012 Nov 2.

Novel 3-Azaindolyl-4-arylmaleimides exhibiting potent antiangiogenic efficacy, protein kinase inhibition, and antiproliferative activity

Christopher Ganser  1 , Eva Lauermann, Annett Maderer, Torsten Stauder, Jan-Peter Kramb, Stanislav Plutizki, Thomas Kindler, Markus Moehler, Gerd Dannhardt
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Novel 3-Azaindolyl-4-arylmaleimides exhibiting potent antiangiogenic efficacy, protein kinase inhibition, and antiproliferative activity

V体育ios版 - Christopher Ganser et al. J Med Chem. .

Abstract

Tumor growth and metastasis are highly associated with the overexpression of protein kinases (PKs) regulating cell growth, apoptosis resistance, and prolonged cell survival. This study describes novel azaindolyl-maleimides with significant inhibition of PKs, such as VEGFR, FLT-3, and GSK-3β which are related to carcinogenesis. Furthermore, these compounds exhibit high kinase selectivity and potent inhibition of angiogenesis and cell proliferation, offering versatile options in cancer treatment strategies VSports手机版. .

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