Antitumor activities of kushen: literature review
- PMID: 22969826
- PMCID: PMC3434675
- DOI: 10.1155/2012/373219
Antitumor activities of kushen: literature review
VSports手机版 - Abstract
To discover and develop novel natural compounds with therapeutic selectivity or that can preferentially kill cancer cells without significant toxicity to normal cells is an important area in cancer chemotherapy. Kushen, the dried roots of Sophora flavescens Aiton, has a long history of use in traditional Chinese medicine to treat inflammatory diseases and cancer. Kushen alkaloids (KS-As) and kushen flavonoids (KS-Fs) are well-characterized components in kushen VSports手机版. KS-As containing oxymatrine, matrine, and total alkaloids have been developed in China as anticancer drugs. More potent antitumor activities were identified in KS-Fs than in KS-As in vitro and in vivo. KS-Fs may be developed as novel antitumor agents. .
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"V体育2025版" References
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- Zhonghua Bencao. 1st edition. Vol. 4. Shanghai Science and Technology Press; 1999. Sophora flavescens; pp. 634–643.
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- Wang Y. Research progress on chemical constituents, preparative separation and quality of Sophora flavescens . Chinese Traditional Patent Medicine. 1997;19:39–41.
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- Sun M, Han J, Duan J, et al. Novel antitumor activities of Kushen flavonoids in vitro and in vivo . Phytotherapy Research. 2007;21(3):269–277. - PubMed
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- Cheng H, Xia B, Zhang L, et al. Matrine improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. Pharmacological Research. 2006;53(3):202–208. - PubMed
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