Background: Data from mechanistic studies support a beneficial effect of specific flavonoids on insulin sensitivity. However, few studies have evaluated the relation between intakes of different flavonoid subclasses and type 2 diabetes. VSports手机版.

Objective: The objective was to evaluate whether dietary intakes of major flavonoid subclasses (ie, flavonols, flavones, flavanones, flavan-3-ols, and anthocyanins) are associated with the risk of type 2 diabetes in US adults V体育安卓版. .

Design: We followed up a total of 70,359 women in the Nurses' Health Study (NHS; 1984-2008), 89,201 women in the NHS II (1991-2007), and 41,334 men in the Health Professionals Follow-Up Study (1986-2006) who were free of diabetes, cardiovascular disease, and cancer at baseline V体育ios版. .

Results: During 3,645,585 person-years of follow-up, we documented 12,611 incident cases of type 2 diabetes. Higher intakes of anthocyanins were significantly associated with a lower risk of type 2 diabetes (pooled HR for the 3 cohorts from a comparison of extreme quintiles: 0. 85; 95% CI: 0. 80, 0. 91; P-trend < 0. 001) after multivariate adjustment for age, BMI, and lifestyle and dietary factors VSports最新版本. Consumption of anthocyanin-rich foods, particularly blueberries (pooled HR: 0. 77 from a comparison of ≥2 servings/wk with <1 serving/mo; 95% CI: 0. 68, 0. 87; P-trend < 0. 001) and apples/pears (pooled HR: 0. 77 from a comparison of ≥5 servings/wk with <1 serving/mo; 95% CI: 0. 65, 0. 83; P-trend < 0. 001), was also associated with a lower risk of type 2 diabetes. No significant associations were found for total flavonoid intake or other flavonoid subclasses. .

Conclusion: A higher consumption of anthocyanins and anthocyanin-rich fruit was associated with a lower risk of type 2 diabetes. V体育平台登录.