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Review
. 2011 Nov;32(11):2229-35.
doi: 10.1016/j.peptides.2011.07.003. Epub 2011 Jul 12.

"VSports注册入口" Physiological roles revealed by ghrelin and ghrelin receptor deficient mice

Rosie G Albarran-Zeckler  1 , Yuxiang Sun, Roy G Smith
Affiliations
Review

Physiological roles revealed by ghrelin and ghrelin receptor deficient mice

Rosie G Albarran-Zeckler et al. Peptides. 2011 Nov.

"V体育2025版" Abstract

Ghrelin is a hormone made in the stomach and known primarily for its growth hormone releasing and orexigenic properties. Nevertheless, ghrelin through its receptor, the GHS-R1a, has been shown to exert many roles including regulation of glucose homeostasis, memory & learning, food addiction and neuroprotection. Furthermore, ghrelin could promote overall health and longevity by acting directly in the immune system and promoting an extended antigen repertoire. The development of mice lacking either ghrelin (ghrelin-/-) or its receptor (ghsr-/-) have provided a valuable tool for determining the relevance of ghrelin and its receptor in these multiple and diverse roles. In this review, we summarize the most important findings and lessons learned from the ghrelin-/- and ghsr-/- mice. VSports手机版.

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Figures

Figure 1
Figure 1
Leptin deficient mice (ob/ob) are morbidly obese and diabetic. Mice lacking ghrelin and leptin (ghrelin(−/−).ob/ob) are still obese, but have improved glucose tolerance.
Figure 2
Figure 2
Ghrelin increases thymus size and thymocyte cell number in old mice. (A) Ghrelin infusion for 2 weeks increased thymus size in 14-month-old animals; (B) ghrelin increased total thymocyte numbers in 14-, 20- and 24-month-old mice. Reproduced with permission from the American Society for Clinical Investigation (Dixit, V.D., et al., Ghrelin promotes thymopoiesis during aging. J Clin
Figure 3
Figure 3
Ghrelin infusion into 14-months old mice increases cellularity and reduces lipid deposits in the thymus. Vehicle (A, C, E); ghrelin infusion (B, D, F); Oil Red O staining illustrates decreased lipid deposits in response to ghrelin (E, F). Reproduced with permission from the American Society for Clinical Investigation (Dixit, V.D., et al., Ghrelin promotes thymopoiesis during aging. J Clin Invest, 2007. 117(10): p. 2778-90.)
Figure 4
Figure 4
Ghrelin and GHS-R–deficient mice exhibit accelerated age-associated thymic involution. (A) Thymocyte counts in 2 and 24 mo WT, ghrelin-/- and ghsr-/- mice. (B) Histology of thymus from 24 mo ghrelin-/- and ghsr-/- mice revealing loss of CMJs, reduced cellularity, and increased adipocytes. Reproduced with permission from the American Society for Clinical Investigation (Dixit, V.D., et al., Ghrelin promotes thymopoiesis during aging. J Clin Invest, 2007. 117(10): p. 2778-90.)
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