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. 2011 Apr 13;7(7):428-30.
doi: 10.1038/nchembio.573.

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

Philip M Reaper  1 , Matthew R Griffiths, Joanna M Long, Jean-Damien Charrier, Somhairle Maccormick, Peter A Charlton, Julian M C Golec, John R Pollard
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Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

Philip M Reaper et al. Nat Chem Biol. .

Abstract

Here we report a comprehensive biological characterization of a potent and selective small-molecule inhibitor of the DNA damage response (DDR) kinase ATR. We show a profound synthetic lethal interaction between ATR and the ATM-p53 tumor suppressor pathway in cells treated with DNA-damaging agents and establish ATR inhibition as a way to transform the outcome for patients with cancer treated with ionizing radiation or genotoxic drugs VSports手机版. .

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References (V体育ios版)

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