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Review
. 2011 Jan:1215:117-22.
doi: 10.1111/j.1749-6632.2010.05848.x.

V体育安卓版 - Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease

Anna Csiszar  1
Affiliations
Review

Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease

Anna Csiszar (VSports最新版本). Ann N Y Acad Sci. 2011 Jan.

Abstract

Cardiovascular diseases are the most common cause of death among the elderly in the Western world. Resveratrol (3,5,4'-trihydroxystilbene) is a plant-derived polyphenol that was shown to exert diverse anti-aging activity mimicking some of the molecular and functional effects of caloric restriction. This mini-review focuses on the molecular and cellular mechanisms activated by resveratrol in the vascular system, and explores the links between its anti-oxidative and anti-inflammatory effects, which could be exploited for the prevention or amelioration of vascular aging in the elderly. VSports手机版.

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V体育官网 - Figures

Figure 1
Figure 1
Proposed scheme for the mechanisms by which resveratrol confers anti-oxidative and anti-inflammatory vasoprotective effects in aging. During aging increased NADPH oxidase- and mitochondria-derived ROS production enhances NF-κB activation, which promotes inflammatory cytokine and chemokine expression, endothelial activation and leukocyte adhesion. Increased oxidative stress also impairs endothelial vasomotor function and promotes endothelial apoptosis, which together with chronic low-grade vascular inflammation significantly increase the risk for the development of vascular diseases in the elderly. The model predicts that resveratrol, via up-regulating Nrf2-driven antioxidant enzymes and eNOS, down-regulating TNFα-activated NADPH oxidases, exerting mitochondrial protective effects and inhibiting NF-κB, significantly attenuates vascular oxidative stress and inflammation in aging. Empty block arrows: inhibition; filled block arrows: induction/activation.
See this image and copyright information in PMC

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