Protective effects of icariin on cognitive deficits induced by chronic cerebral hypoperfusion in rats
- PMID: 19215241
- DOI: 10.1111/j.1440-1681.2009.05149.x
Protective effects of icariin on cognitive deficits induced by chronic cerebral hypoperfusion in rats
Abstract
1. Icariin is a major constituent of flavonoids derived from the Chinese medicinal herb Epimedium revicornum Maxim. The aim of the present study was to investigate whether icariin has protective effects on learning ability and memory in a rat model of chronic cerebral hypoperfusion. 2. Chronic cerebral hypoperfusion was induced by permanent ligation of the common carotid artery in Wistar rats for 4 months. One month after permanent artery occlusion, rats were adminitered icariin at doses of 0, 30, 60 or 120 mg/kg per day, p. o. , for 3 months. Neurobehavioural and neurobiochemical parameters were examined to evaluate the effects of icariin on cognitive deficits induced by chronic cerebral hypoperfusion. 3. The Morris water maze test revealed that learning ability and memory were severely impaired in untreated rats, but were significantly improved in icariin-treated rats. Icariin treatment also ameliorated chronic cerebral hypoperfusion-induced oxidative stress in the brain, as evidenced by reduced malondialdehyde formation and maintained superoxide dismutase activity. In addition, the decreased hippocampal levels of acetylcholine, acetylcholinesterase and choline acetyltransferase associated with chronic cerebral hypoperfusion were significantly prevented by icariin treatment VSports手机版. 4. In conclusion, icariin protects against cognitive deficits induced by chronic cerebral hypoperfusion in rats. These effects appear to be mediated through its anti-oxidant effects, as well as its effects on the circulatory and cholinergic systems. .
Publication types
MeSH terms
- Actions (VSports注册入口)
- "V体育2025版" Actions
- Actions (V体育官网入口)
- Actions (V体育ios版)
- "V体育ios版" Actions
- V体育ios版 - Actions
- "VSports注册入口" Actions
- Actions (V体育安卓版)
- VSports在线直播 - Actions
- "V体育官网入口" Actions
- Actions (VSports)
- "VSports app下载" Actions
- "VSports注册入口" Actions
- V体育官网入口 - Actions
- "VSports手机版" Actions
Substances
- Actions (VSports注册入口)
- Actions (VSports手机版)
LinkOut - more resources
Full Text Sources