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. 1991 Aug;12(8):1503-6.
doi: 10.1093/carcin/12.8.1503.

V体育ios版 - A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

N Ito  1 , R Hasegawa, M Sano, S Tamano, H Esumi, S Takayama, T Sugimura
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"VSports注册入口" A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

N Ito et al. Carcinogenesis. 1991 Aug.

Abstract

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), which is produced during cooking and is mutagenic to bacteria and cultured mammalian cells, was found to induce high incidences of colon and mammary carcinomas in F344 rats when administered at a concentration of 400 p. p. m. in the diet for 52 weeks. Since PhIP is the most abundant of the mutagenic heterocyclic amines in cooked meat and fish, the compound might be related to malignancies of the colon and breast in humans VSports手机版. .

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