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Comparative Study
. 2007 Oct;137(4):659-64.
doi: 10.1016/j.otohns.2007.04.026.

"V体育平台登录" The characteristics of Hep-2 cell with multiple drug resistance induced by Taxol

Li Li  1 , Alice C Jiang, Pin Dong, Yi Wan, Zi Wei Yu
Affiliations
Comparative Study

The characteristics of Hep-2 cell with multiple drug resistance induced by Taxol

Li Li et al. Otolaryngol Head Neck Surg. 2007 Oct.

Abstract

Objective: To investigate the characteristics of Hep-2 cell with multidrug resistance (MDR) induced by Taxol. VSports手机版.

Study design: Hep-2 cells were exposed in stepwise escalating concentration of Taxol to develop the resistant cell line-Hep-2T V体育安卓版. Cell cycle distribution, apoptosis, and rhodamine accumulation were studied through flow cytometry. The MDR1 and MRP1 genes were detected through real-time quantitative RT-PCR, and the corresponding proteins were detected through Western blotting. .

Results: The drug resistance of Hep-2T cells to Taxol, doxorubicin, gemcitabine, 5-FU, and cisplatin all increased. The percentage of G0/G1 phase and the antiapoptosis ability increased significantly compared with Hep-2 cells. Both MDR1 and MRP1 also increased at gene and protein level, though MDR1 was more prominent V体育ios版. .

Conclusion: More emphasis should be laid on MDR1/Pgp, the non-Pgp substrate chemotherapeutic agents, and the changes of cell cycle distribution to prevent MDR induced by Taxol. VSports最新版本.

Significance: These findings may provide theoretical support for the reverse of MDR. V体育平台登录.

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