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. 2006 Dec 14;49(25):7549-53.
doi: 10.1021/jm0609871.

Profile and molecular modeling of 3-(indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H-pyrrole-2,5-dione (1) as a highly selective VEGF-R2/3 inhibitor

Christian Peifer  1 , Agata Krasowski, Nina Hämmerle, Oliver Kohlbacher, Gerd Dannhardt, Frank Totzke, Christoph Schächtele, Stefan Laufer
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V体育ios版 - Profile and molecular modeling of 3-(indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H-pyrrole-2,5-dione (1) as a highly selective VEGF-R2/3 inhibitor

Christian Peifer et al. J Med Chem. .

"VSports" Abstract

We report on selectivity profiling of 1 in a panel of 20 protein kinases and molecular modeling indicating 1 to be highly active and selective for VEGF-R2/3 VSports手机版. Sequence alignment analysis and detailed insights into the ATP binding pockets of targeted protein kinases from the panel result in a unique structural architecture of VEGF-R2 mainly caused by the hydrophobic pocket I, determining the molecular basis for activity and selectivity of 1. .

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