Objectives: To find possible association between liver enzymes and mortality in older people VSports手机版. .

Design: A prospective cohort study V体育安卓版. .

Setting: Jerusalem V体育ios版. .

Participants: A systematically selected representative sample of 455 70-year-old ambulatory individuals was prospectively followed for 12 years VSports最新版本. .

Measurements: An extensive social and medical profile was developed at age 70 using a detailed interview and physical and ancillary examination. Information on mortality was obtained annually. Differences in survival between subjects stratified according to liver enzyme levels were assessed using the Kaplan-Meier method. Multivariable survival analyses using a Cox proportional hazards model were performed to determine the association between liver enzyme levels at age 70 and mortality over 12 years V体育平台登录. .

Results: Median alanine aminotransferase (ALT) activity of the study population was 11. 00 U/L for women and 13. 00 U/L for men. Twelve-year survival rates for women with ALT below and above the median levels were similar (78%). For men, these rates were 54% and 65%, respectively (P < . 001). Proportional hazards models demonstrated that this greater mortality risk was independent of numerous common risk factors for mortality (hazard ratio (HR) = 1. 5, 95% confidence interval (CI) = 1. 08-2. 19) VSports注册入口. Adding an interaction between sex and low ALT to the model demonstrated a higher risk of mortality for men with low ALT levels (HR = 2. 42, 95% CI = 1. 15-5. 08). No such risk was demonstrated for the other liver enzymes. .

Conclusion: ALT activity represents a strong and independent surrogate marker for mortality in community-dwelling elderly men V体育官网入口. .