The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease (VSports最新版本)
- PMID: 17008526
- DOI: 10.1126/science.1132939
"VSports手机版" The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
Abstract
To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project VSports手机版. .
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"V体育安卓版" The connectivity map.Nat Chem Biol. 2006 Dec;2(12):663-4. doi: 10.1038/nchembio1206-663. Nat Chem Biol. 2006. PMID: 17108982 No abstract available.
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