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. 2006 Sep 29;313(5795):1929-35.
doi: 10.1126/science.1132939.

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease (VSports最新版本)

Justin Lamb  1 , Emily D Crawford, David Peck, Joshua W Modell, Irene C Blat, Matthew J Wrobel, Jim Lerner, Jean-Philippe Brunet, Aravind Subramanian, Kenneth N Ross, Michael Reich, Haley Hieronymus, Guo Wei, Scott A Armstrong, Stephen J Haggarty, Paul A Clemons, Ru Wei, Steven A Carr, Eric S Lander, Todd R Golub
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"VSports手机版" The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

Justin Lamb et al. Science. .

Abstract

To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project VSports手机版. .

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