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. 2006 Mar;21(3):413-8.
doi: 10.1359/JBMR.051205. Epub 2005 Dec 19.

Long-term fracture prediction by DXA and QUS: a 10-year prospective study

Alison Stewart  1 , Vinod Kumar, David M Reid
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Long-term fracture prediction by DXA and QUS: a 10-year prospective study (VSports在线直播)

Alison Stewart et al. J Bone Miner Res. 2006 Mar.
Free article

VSports app下载 - Abstract

This study investigated the ability of DXA and QUS to predict fractures long term when measured around the time of the menopause VSports手机版. We found both DXA and QUS are able to predict both any fracture and "osteoporotic" fractures and that QUS can predict independently of BMD. .

Introduction: There are now many treatments available for prevention of osteoporotic fracture. To be cost-effective, we need to target those most at risk V体育安卓版. This study examines the ability of DXA and QUS to predict fractures in an early postmenopausal population of women. .

Materials and methods: We prospectively measured 3883 women who had been randomly selected from a community-based register V体育ios版. At baseline, they were measured using DXA of spine and hip (Norland XR-26) and QUS of the heel (Walker Sonix UBA 575). Follow-up had a mean of 9. 7 +/- 1. 1 (SD) years. All incident fractures were identified and validated by examination of X-ray reports, and these were compared with those without fracture in a Cox-regression model to calculate hazard ratios (HRs). .

Results: We found adjusted HRs for any fracture per 1 SD reduction in spine BMD to be 1. 61 (1. 42-1. 83), whereas neck of femur BMD was 1. 54 (1. 34-1. 75). Areas under the curve (AUC) for a receiver operator characteristic (ROC) analysis were 0. 62 for spine BMD and 0. 59 for neck BMD. In a subgroup where QUS was also measured, the HR for a 1 SD reduction in BMD was 1. 69 (1. 29-2. 22) for spine BMD and 1. 55 (1. 17-2. 06) for neck BMD. The HR for a 1 SD reduction in broadband ultrasound attenuation (BUA) was 1. 53 (1. 19-1. 96), and 1. 44 (1. 12-1. 86) when further adjusted for neck BMD. The AUCs were 0. 63 for spine BMD, 0. 59 for neck BMD, and 0 VSports最新版本. 62 for BUA. When only osteoporotic fractures were examined, the HRs increased in all situations. BUA showed the highest HR of 2. 25 (1. 51-3. 34), and when further adjusted for neck BMD was 2. 12 (1. 38-3. 28). .

Conclusions: In conclusion, it may be possible to scan women around the time of the menopause to predict future fractures. It seems that, for "osteoporotic" fractures, BUA may be an improved predictor of fractures in comparison with DXA, because the relative risk is highest for BUA, and independent of BMD. V体育平台登录.

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