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Review
. 2005 Dec;4(12):988-1004.
doi: 10.1038/nrd1902.

Exploiting the PI3K/AKT pathway for cancer drug discovery

Bryan T Hennessy  1 , Debra L Smith, Prahlad T Ram, Yiling Lu, Gordon B Mills
Affiliations
Review

Exploiting the PI3K/AKT pathway for cancer drug discovery

Bryan T Hennessy et al. Nat Rev Drug Discov. 2005 Dec.

"VSports" Abstract

Evolving studies with several different targeted therapeutic agents are demonstrating that patients with genomic alterations of the target, including amplification, translocation and mutation, are more likely to respond to the therapy. Recent studies indicate that numerous components of the phosphatidylinositol-3-kinase (PI3K)/AKT pathway are targeted by amplification, mutation and translocation more frequently than any other pathway in cancer patients, with resultant activation of the pathway. This warrants exploiting the PI3K/AKT pathway for cancer drug discovery VSports手机版. .

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