Aim: To study the anti-tumor effect of resveratrol and in combination with 5-FU on murine liver cancer VSports手机版. .

Methods: Transplantable murine hepatoma22 model was used to evaluate the anti-tumor activity of resveratrol (RES) alone or in combination with 5-FU in vivo. H22 cell cycles were analyzed with flow cytometry V体育安卓版. .

Results: Resveratrol could inhibit the growth of murine hepatoma22, after the mice bearing H22 tumor were treated with 10 mg/kg or 15 mg/kg resveratrol for ten days, and the inhibition rates were 36. 3% (n = 10) and 49. 3% (n = 9), respectively, which increased obviously compared with that in control group (85+/-22 vs 68+/-17, P<0 V体育ios版. 01). RES could induce the S phase arrest of H22 cells, and increase the percentage of cells in S phase from 59. 1% (n = 9) to 73. 5% (n = 9) in a dose-dependent manner (P<0. 05). The enhanced inhibition of tumor growth by 5-FU was also observed in hepatoma22 bearing mice when 5-FU was administered in combination with 10 mg/kg resveratrol. The inhibition rates for 20 mg/kg or 10 mg/kg 5-FU in combination with 10 mg/kg resveratrol were 77. 4% and 72. 4%, respectively, compared with the group of 20 mg/kg or 10 mg/kg 5-FU alone, in which the inhibition rates were 53. 4% and 43. 8%, respectively (n = 8). There was a statistical significance between the combination group and 5-FU group. .

Conclusion: RES could induce the S phase arrest of H22 cells and enhance the anti-tumor effect of 5-FU on murine hepatoma22 and antagonize its toxicity markedly VSports最新版本. These results suggest that resveratrol, as a biochemical modulator to enhance the therapeutic effects of 5-FU, may be potentially useful in cancer chemotherapy. .