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. 2004 Apr 24;328(7446):983.
doi: 10.1136/bmj.38050.593634.63. Epub 2004 Mar 17.

Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study

Hyeon Chang Kim  1 , Chung Mo Nam, Sun Ha Jee, Kwang Hyub Han, Dae Kyu Oh, Il Suh
Affiliations

Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study

Hyeon Chang Kim et al. BMJ. .

Abstract (VSports注册入口)

Objective: To examine the relation between the normal range of serum aminotransferase concentration and mortality from liver disease. VSports手机版.

Design: Prospective cohort study. V体育安卓版.

Setting: Korea Medical Insurance Corporation study with eight years' follow up V体育ios版. .

Participants: 94,533 men and 47,522 women aged 35-59 years VSports最新版本. .

Main outcome measure: Mortality from liver diseases according to death certificate. V体育平台登录.

Results: There was a positive association between the aminotransferase concentration, even within normal range (35-40 IU/l), and mortality from liver disease. Compared with the concentration < 20 IU/l, the adjusted relative risks for an aspartate aminotransferase concentration of 20-29 IU/l and 30-39 IU/l were 2. 5 (95% confidence interval 2. 0 to 3. 0) and 8. 0 (6. 6 to 9. 8) in men and 3. 3 (1. 7 to 6. 4) and 18. 2 (8. 1 to 40. 4) in women, respectively, The corresponding risks for alanine aminotransferase were 2. 9 (2. 4 to 3. 5) and 9. 5 (7. 9 to 11. 5) in men and 3. 8 (1 VSports注册入口. 9 to 7. 7) and 6. 6 (1. 5 to 25. 6) in women, respectively. According to receiver operating characteristic curves the best cut-off values for the prediction of liver disease in men were 31 IU/l for aspartate aminotransferase and 30 IU/l for alanine aminotransferase. .

Conclusion: People with slightly increased aminotransferase activity, but still within the normal range, should be closely observed and further investigated for liver diseases V体育官网入口. .

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V体育平台登录 - Figures

Fig 1
Fig 1
Receiver operating characteristic (ROC) curves of serum aminotransferase concentration for identification of people at risk of death from liver diseases
Fig 2
Fig 2
Association between serum aminotransferase concentration and mortality from liver disease in men by presence of family history of liver disease (expressed as floating absolute risks)
See this image and copyright information in PMC

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References

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