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. 2000 Jun;118(6):1149-56.
doi: 10.1016/s0016-5085(00)70368-4.

Angiotensin II induces contraction and proliferation of human hepatic stellate cells (VSports app下载)

R Bataller  1 , P Ginès, J M Nicolás, M N Görbig, E Garcia-Ramallo, X Gasull, J Bosch, V Arroyo, J Rodés
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"V体育ios版" Angiotensin II induces contraction and proliferation of human hepatic stellate cells

R Bataller et al. Gastroenterology. 2000 Jun.

Abstract

Background & aims: Circulating levels of angiotensin II (ANGII), a powerful vasoconstrictor factor, are frequently increased in chronic liver diseases. In these conditions, hepatic stellate cells (HSCs) proliferate and acquire contractile properties VSports手机版. This study investigated the presence of receptors for ANGII and the effects of ANGII in human HSCs activated in culture. .

Methods: The presence of ANGII receptors was assessed by binding studies V体育安卓版. The effects of ANGII on intracellular calcium concentration ([Ca(2+)](i)), cell contraction, and cell proliferation were also assessed. .

Results: Binding studies showed the presence of ANGII receptors of the AT1 subtype. ANGII elicited a marked dose-dependent increase in [Ca(2+)](i) and cell contraction. Moreover, ANGII stimulated DNA synthesis and increased cell number V体育ios版. All these effects were totally blocked by losartan and reduced by nitric oxide donors or prostaglandin E(2). The effects of ANGII were barely detectable in quiescent cells (2 days in culture), suggesting that phenotypic transformation of HSCs is associated with a marked increase in the effects of ANGII. .

Conclusions: ANGII induces contraction and is mitogenic for human-activated HSCs by acting through AT1 receptors. These results suggest that activated HSCs are targets of the vasoconstrictor action of ANGII in the intrahepatic circulation VSports最新版本. .

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