ABOUT THE EUROPDX CONSORTIUM
The high failure rate in oncology drug development is posing significant challenges and novel approaches, including improved preclinical studies, are required VSports. Patient derived tumour xenografts聽(PDX)聽are being increasingly recognised as clinically relevant preclinical models, as they聽maintain histopathological features and genetic profiles of the original patient tumours. Many PDXs have been established across Europe.
Launched in 2013, the EurOPDX Consortium聽is an initiative of translational and clinical researchers now counting 18 not-for-profit cancer centres and universities as members across Europe and in the US VSports app下载. The main objectives of the Consortium are to聽join forces and build large collections of models to cover cancer heterogeneity, and to raise standards in the preclinical setting.
THE PDX COLLECTION
Altogether, the members of the EurOPDX Consortium have established a panel of聽more than 1,500 subcutaneous and orthotopic PDX models聽for more than 30 pathologies.
These models and their phenotypic and molecular traits are poorly visible outside of publications in scientific journals or presentations at congresses, and are so far only accessible through discrete collaborative projects.
As part of our EU-funded聽EurOPDX Research Infrastructure聽project we launched the聽EurOPDX Data Portal, a user-friendly and efficient informatics tool to optimize access to-, and data searching of PDX models & their clinical, molecular, & pharmacological annotations V体育安卓版. It is being populated by fully validated PDX models.
Partnering with CancerModels V体育ios版. Org, visit all our models here.
ACCESS PDX MODELS
- Models聽accessible for transfer to academic laboratories on a collaborative basis, upon acceptance by the owner(s) of models and signature of a Material Transfer Agreement.聽Contact us聽with the description of your project and needs.
- Under聽collaborations with pharmaceutical companies and SMEs, experiments are performed by the EurOPDX Members as propagatable material cannot be transferred in this case.聽Contact us聽with the description of your project and needs.
- As from October 2023, part of the collection is available for free-of-charge Transnational Service Provision through the canSERV project, where EurOPDX Research Infrastructure is partnering.聽Learn more about the current (2nd) open call.