Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes (V体育2025版)

Mendelian Randomization Study of Obesity and Cerebrovascular Disease

Marini1, Merino2, Montgomery3 et al. 2020Annals of NeurologySelf Cite13651041Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…ICH was subclassified into lobar and nonlobar ICH, given the different pathophysiology by location . Genetic data for ischemic stroke (including the etiological subtypes) and for ICH were derived from the MEGASTROKE consortium and the International Stroke Genetics Consortium GWAS for ICH, respectively. In brief we utilized the results obtained from inverse‐variance meta‐analysis restricted to subjects of European ancestry after adjusting for age, sex, and principal components reflecting ancestry (40,585 cases; 406,111 controls). …”Section: Methodsmentioningconfidence: 99%“…Genotyping and bioinformatic genetic analysis of each of these GWAS followed standardized procedures that are harmonized and comparable across the studies. Detailed genotype and phenotype assessment procedures have been previously published . Additional demographic and phenotypic information on the included studies is available in the Table. …”Section: Methodsmentioningconfidence: 99%“…Ischemic stroke was analyzed in toto (all-cause ischemic strokes) and further as subclassified into large-artery atherosclerotic stroke (LAS), cardioembolic stroke (CES), and small vessel stroke (SVS). 9 ICH was subclassified into lobar and nonlobar ICH, given the different pathophysiology by location. 10 Genetic data for ischemic stroke (including the etiological subtypes) and for ICH were derived from the MEGASTROKE consortium 9 and the International Stroke Genetics Consortium GWAS for ICH, 11 respectively. …”Section: Traits Analyzed and Genome-wide Association Studiesmentioningconfidence: 99%“…Detailed genotype and phenotype assessment procedures have been previously published. 8,9,11,[19][20][21] Additional demographic and phenotypic information on the included studies is available in the Table VSports app下载. …”Section: Traits Analyzed and Genome-wide Association Studiesmentioningconfidence: 99%See 2 more Smart Citations

Mendelian Randomization Study of Obesity and Cerebrovascular Disease (VSports手机版)

Marini1, Merino2, Montgomery3 et al. 2020Annals of NeurologySelf Cite13651041Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Rare genetic variants, imbalanced case control ratios, phenotypic outliers (Stranger et al, ), or non‐normally distributed phenotypes can lead to scenarios in which standard asymptotic theory does not provide reliable results. For some test statistics of interest, for example in gene‐based/region‐based analysis (Chen, Hsu, Gamazon, Cox, & Nicolae, ; Lee, Abecasis, Boehnke, & Lin, ; Liu et al, ; Mishra & Macgregor, ), the asymptotic distribution of the test statistic is even not tractable and permutation/simulation procedures have to be applied, which can be computationally challenging (Malik et al, ; Sugasawa, Noma, Otani, Nishino, & Matsui, ). …”Section: Introductionmentioningconfidence: 99%

A flexible and nearly optimal sequential testing approach to randomized testing: QUICK‐STOP (VSports app下载)

Hecker1, Ruczinski2, Cho3 et al. 2019Genetic Epidemiology6090Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

Associations of Combined Genetic and Lifestyle Risks With Incident Cardiovascular Disease and Diabetes in the UK Biobank Study

Said1, Verweij2, Harst3 2018JAMA CardiolSelf Cite516173743Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.