A Case of Invasive Mucinous Pulmonary Adenocarcinoma with a CD74-NRG1 Fusion Protein Targeted with Afatinib (VSports在线直播)

Dual Targeting of ERBB2/ERBB3 for the Treatment of SLC3A2-NRG1–Mediated Lung Cancer

Shin1, Jo2, Han3 2018Molecular Cancer Therapeutics341220Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…In contrast, ERBB2 shows a constitutively activated conformation similar to that of ligand-bound EGFR. If we confirm our in vitro results in in vivo system that ERBB2 is promising target of SLC3A2-NRG1-mediated lung cancer, LSL-KRAS G12D and ERBB2 conditional knockout mice in lung should be generated like ERBB2-deficient conditional mutant mice in cardiomyocyte (25). The mice lung of KRAS G12D(þ)/ERBB2(þ) and KRAS G12D (þ)/ERBB2 (À) were infected by adenovirus particles of SLC3A2-NRG1. …”Section: Discussionsupportingconfidence: 63%

Dual Targeting of ERBB2/ERBB3 for the Treatment of SLC3A2-NRG1–Mediated Lung Cancer

Shin1, Jo2, Han3 2018Molecular Cancer Therapeutics341220Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The specific NRG1 fusion partners are variable within and across tumor types (11)(12)(13)(14)(15)20). Several novel fusion partners detected in this report include TNC, MRPL13, MDK, and DIP2B in NSCLC. …”Section: Discussionmentioningconfidence: 65%“…Dual targeting of ERBB2 and ERBB3 has also been evaluated in preclinical models (22,23). Afatinib, a pan-ERBB inhibitor, was successfully utilized in this manner, and several patients with tumor harboring an NRG1 fusion achieved durable benefit with afatinib (11)(12)(13). Response to an ERBB3 mAb, GSK2849330, has also been reported (9). …”Section: Discussionmentioningconfidence: 99%“…When NRG1 fusions are present, targeting ERBB2 and ERBB3 has been an effective treatment strategy in vitro. Recently, clinical responses to tyrosine kinase inhibitors and mAbs have also been reported (9,(11)(12)(13). …”Section: Introductionmentioningconfidence: 99%See 1 more Smart Citation

Detection of NRG1 Gene Fusions in Solid Tumors

Jonna1, Feldman2, Swensen3 et al. 2019Clinical Cancer Research207122113Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…1C). 2,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] In one report, the presence of NRG1 fusions confers a poor survival among mucinous lung adenocarcinoma. 14 Given the rarity of NRG1þ NSCLC, a basic understanding of the genomic structure of the NRG1 will help our appreciation of the potential complexities in detecting NRG1þ NSCLC. …”mentioningconfidence: 99%

Neuregulin 1 Fusion–Positive NSCLC

Nagasaka1, Ou2 2019Journal of Thoracic Oncology310300Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility VSports. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.