"VSports在线直播" Reprogramming of stromal fibroblasts by SNAI2 contributes to tumor desmoplasia and ovarian cancer progression

Cancer-associated Fibroblast–promoted LncRNA DNM3OS Confers Radioresistance by Regulating DNA Damage Response in Esophageal Squamous Cell Carcinoma

Zhang1, Hua2, Jiang3 et al. 2019Clinical Cancer Research14211151Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The members of tumor microenvironment, such as CAFs, transfer energy and biomass to support tumor cells growth and survival in response to death stimulus (3). In parallel, tumor cells facilitate the transformation of normal fibroblasts into CAFs, which in turn enhance the malignant ability of tumor cells (4,25). Our previous studies revealed that CAFs were involved in tumor chemoradioresponse by secretion of chemokines and cytokines (7,8). …”Section: Discussionmentioningconfidence: 97%“…The complicated interaction between tumor cells and their host microenvironment has important influences on their biological behavior. Tumor cells promote the growth and survival of stromal fibroblasts; in parallel, the microenvironment potentiates the activation of signaling pathways that are involved in proliferation, invasion, and survival of tumor cells (4)(5)(6). Our previous study revealed that the cross-talk of esophageal cancer cells and CAFs induced TGFb1 expression in an autocrine/paracrine signaling loop, which resulted in the development of chemoresistance (7). …”Section: Introductionmentioningconfidence: 99%

Cancer-associated Fibroblast–promoted LncRNA DNM3OS Confers Radioresistance by Regulating DNA Damage Response in Esophageal Squamous Cell Carcinoma

Zhang1, Hua2, Jiang3 et al. 2019Clinical Cancer Research14211151Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…The significant increase in CXCR7 gene expression in the mesenchymal subtype of the ovarian TCGA dataset is highly indicative of a role of CXCR7 in the acquisition of mesenchymal features. Consistent with this, we found a positive correlation of CXCR7 expression with a gene stromal signature built from overlapping genes from the TCGA mesenchymal subtype and the Tothill C1 (tumor desmoplasia) subtype samples that were positively correlated with mesenchymal markers and ECM remodeling (Verhaak et al . , ; Yang et al . , ). Our GSEA of microdissected profiles revealed an enriched expression of CXCR7 in the stromal compartment of ovarian tumors in several datasets. …”Section: Discussionmentioningconfidence: 97%“…Gene expression was normalized to the distribution of each gene in tumors and annotated as z-scores as described (Edjekouane et al, 2016). The mesenchymal signature score was derived from a subset of overlapping genes from the TCGA mesenchymal OC subtype and the Tothill C1 (tumor desmoplasia) subtype samples that were positively correlated with mesenchymal markers and extracellular matrix (ECM) remodeling (Verhaak et al, 2013;Yang et al, 2017). GRAPHPAD PRISM 6 (La Jolla, CA, USA) was used to perform Pearson correlation test (two-tailed), and significance was set at P < 0. 05. …”Section: Geo and Tcga Gene Expression Datamentioningconfidence: 99%“…Our gene set enrichment analysis (GSEA) of microdissected profiles and TCGA variant subtypes revealed an enriched expression of CXCR7 in the stromal compartment of ovarian tumors. We have defined the correlation analysis of CXCR7 gene expression against a gene stromal signature that was built from overlapping genes of mesenchymal markers and ECM remodeling derived from the TCGA mesenchymal subtype and the Tothill C1 (tumor desmoplasia) datasets (Verhaak et al, 2013;Yang et al, 2017). The signature was discriminately expressed in the different OC subtypes with a significant enrichment in the mesenchymal subtype (Fig. …”Section: Cxcr7 and Cxcl11 Positively Correlate With The Mesenchymal Pmentioningconfidence: 99%See 1 more Smart Citation

Feedback control of the CXCR7/CXCL11 chemokine axis by estrogen receptor α in ovarian cancer

Benhadjeba1, Edjekouane2, Sauvé3 et al. 2018Molecular Oncology350280Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task VSports app下载. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

V体育官网 - Dynamic expression of SNAI2 in prostate cancer predicts tumor progression and drug sensitivity

Mazzu1, Liao2, Nandakumar3 et al. 2022Molecular Oncology171150Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.