Bone Formation Is Coupled to Resorption Via Suppression of Sclerostin Expression by Osteoclasts

SOST, an LNGFR target, inhibits the osteogenic differentiation of rat ectomesenchymal stem cells

Li1, Liu2, Zhao3 et al. 2017Cell Proliferation152190Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD) VSports app下载. Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…SOST is a vital negative regulator of bone formation. It has recently been reported that SOST inhibition increases bone formation in several disorders . Delgado‐Calle et al have shown that SOST inhibition augmented osteoblast numbers, promoted new bone formation and decreased osteoclast number in multiple myeloma‐colonized bone . …”Section: Discussionmentioningconfidence: 99%“…McDonald and his colleague have revealed that the SOST antibody prevented myeloma‐induced bone loss, decreased osteolytic bone lesions and enhanced fracture resistance . Another study has shown that osteoclast‐derived leukaemia inhibitory factor suppresses SOST expression to regulate bone remodelling . Moreover, SOST antibodies increase osteoclast numbers and stimulate the bone formation rate in a mouse model of recessive osteogenesis imperfect (OI) and in adults with moderate OI from a randomized phase 2a trial . …”Section: Discussionmentioningconfidence: 99%“…It has recently been reported that SOST inhibition increases bone formation in several disorders. [38][39][40][41][42] Delgado-Calle et al have shown that SOST inhibition augmented osteoblast numbers, promoted new bone formation and decreased osteoclast number in multiple myeloma-colonized bone. 38 McDonald and his colleague have revealed that the SOST antibody prevented myeloma-induced bone loss, decreased osteolytic bone lesions and enhanced fracture resistance. …”Section: Cohen-kfir Et Al Have Demonstrated That Sirt1 Negatively Regmentioningconfidence: 99%“…39 Another study has shown that osteoclast-derived leukaemia inhibitory factor suppresses SOST expression to regulate bone remodelling. 40 Moreover, SOST antibodies increase osteoclast numbers and stimulate the bone formation rate in a mouse model of recessive osteogenesis imperfect (OI) and in adults with moderate OI from a randomized phase 2a trial. 41,42 In this study, we demonstrated that SOST negatively regulated osteogenesis in EMSCs, which are the progenitors of all tooth tissues, suggesting that targeting SOST may have great prospects in dental tissue regeneration and engineering. …”Section: Cohen-kfir Et Al Have Demonstrated That Sirt1 Negatively Regmentioningconfidence: 99%See 2 more Smart Citations

SOST, an LNGFR target, inhibits the osteogenic differentiation of rat ectomesenchymal stem cells (V体育官网入口)

Li1, Liu2, Zhao3 et al. 2017Cell Proliferation152190Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Sclerostin is a protein encoded by the gene (SOST) and located in human chromosome 17 (17 q11. 2). This protein is produced by osteocytes and has antianabolic effects on bone structure [13,14]. …”Section: Introductionmentioningconfidence: 99%

Survey of the status of iron and sclerostin in major Thalassemia Patients

Moinzadeh1, Keramati2, Jalali3 et al. 2018IJML1031Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

Recent Advances in Promoting Bone Regeneration in Type 2 Diabetes Using Drug Delivery Vehicles and Vehicle‐Free Therapeutics

Afsharian1, Rahimnejad2, Rabiee3 et al. 2025Advanced Therapeutics2000Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.