Human osteopontin: Potential clinical applications in cancer (Review)

The role of integrins in melanoma: a review

Arias‐Mejias1, Warda2, Quattrocchi3 et al. 2020Int J Dermatology392340Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…Another interesting protein in the realm of ECM involved in melanoma pathogenesis is osteopontin (OPN). Osteopontin is a secreted glycophosphoprotein that has diverse roles in tumor metastasis, including cell adhesion, tumor cell proliferation, angiogenesis, and invasion 46 . OPN contains the RGD motif, which is a major binding site for integrins VSports app下载. …”Section: Integrin Role In Primary Tumor Aggressivenessmentioningconfidence: 99%

The role of integrins in melanoma: a review

Arias‐Mejias1, Warda2, Quattrocchi3 et al. 2020Int J Dermatology392340Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…OPN is also a bone associated protein, produced by several bone cell types (osteoblasts and osteoclasts) and extra-osseous tissue (skin, kidney and lung). Due to differences in post-translational modification, OPN's molecule weight ranges from 41 to 75 kDa, and OPN is suggested to have cell type-specific structure and function [70,71]. OPN plays major roles in bone remodeling, inflammation, immune-regulation, and vascularization, as well as in pathologies, including cancer. …”Section: Uterusmentioningconfidence: 99%“…OPN plays major roles in bone remodeling, inflammation, immune-regulation, and vascularization, as well as in pathologies, including cancer. Several studies have evaluated OPN as a biomarker of tumor progression [70]. …”Section: Uterusmentioningconfidence: 99%

Mother and Embryo Cross-Communication

Idelevich1, Vilella2 2020Genes500380Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…This protein undergoes multiple post-translational modifications by phosphorylation and glycosylation variables that can explain the previously described variability in the apparent molecular weights (from 25 to 75 kD). 29 OPN is involved in multiple processes including tissue remodelling, regulation of cellular immunity, pathological chronic inflammatory processes, carcinogenesis as well as cardiovascular diseases. 30 OPN is also involved in several vascular diseases promoting angiogenesis, in parallel with vascular endothelial growth factor (VEGF), through enhanced endothelial cell migration, proliferation and subsequent formation of capillaries, which are essential requirements for the process of angiogenesis. …”Section: Osteopontin (Opn) Is a Sibling Protein (Small Integrin Bindingmentioningconfidence: 99%“…At the protein level, OPN has a molecular weight of about 60 kD. This protein undergoes multiple post‐translational modifications by phosphorylation and glycosylation variables that can explain the previously described variability in the apparent molecular weights (from 25 to 75 kD) . OPN is involved in multiple processes including tissue remodelling, regulation of cellular immunity, pathological chronic inflammatory processes, carcinogenesis as well as cardiovascular diseases . …”Section: Introductionmentioningconfidence: 99%

"VSports手机版" Co‐culture of human fibroblasts, smooth muscle and endothelial cells promotes osteopontin induction in hypoxia

Sadaghianloo1, Contenti2, Dufies3 et al. 2020J Cellular Molecular Medi8060Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.