Translation of CircRNAs (V体育2025版)

Proper splicing contributes to visual function in the aging Drosophila eye

Stegeman1, Hall2, Escobedo3 et al. 2018Aging Cell435540Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract“…We observed both differential splicing and circRNA increases at Calx (Supporting Information Figure S3). Two recent reports suggest that a subset of circRNAs are translated, suggesting potential regulatory roles during aging (Legnini et al, 2017; Pamudurti et al, 2017). Like the translated circRNAs identified in these studies, the Calx circRNA contains a start codon and could be a potential target for translation; however, we have not examined this possibility. …”Section: Discussionmentioningconfidence: 99%

Proper splicing contributes to visual function in the aging Drosophila eye

Stegeman1, Hall2, Escobedo3 et al. 2018Aging Cell435540Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task VSports app下载. show abstract“…Although expression of the endogenous peptide encoded by circMbl was barely detectable in total fly lysates, immunoblot analysis revealed a band of the expected size (slightly smaller than 10 kDa) in a synaptosomal fraction prepared from fly heads (Pamudurti et al, 2017). The signal intensity for this band was increased by starvation, which promotes cap-independent translation, or by overexpression of FOXO, which inhibits cap-dependent translation. …”Section: Circular Rnas (1) Circmblmentioningconfidence: 96%“…Indeed, the expression of the V5-tagged polypeptide encoded by circMbl was not affected by overexpression of the protein 4E-BP, which inhibits cap-dependent translation. Moreover, both in vivo and in vitro assays revealed that the untranslated region of circMbl supports cap-independent translation, suggesting the presence of a putative IRES element (Pamudurti et al, 2017). …”Section: Circular Rnas (1) Circmblmentioningconfidence: 99%“…Analysis of published ribosome footprinting data sets resulted in the identification of 37 circRNAs that contain reads of the footprinting across the circRNA-specific junctions in Drosophila, suggesting that these circRNAs are actually translated (Pamudurti et al, 2017). …”Section: Circular Rnas (1) Circmblmentioningconfidence: 99%“…Indeed, recent studies have shown that endogenous peptides are produced by circRNAs in a cap-independent manner (Fig. 1B) ( Legnini et al, 2017;Pamudurti et al, 2017). Some circRNAs have even been found to generate proteins containing >100 amino acids (Legnini et al, 2017). …”Section: Introductionmentioningconfidence: 96%See 2 more Smart Citations

Hidden Peptides Encoded by Putative Noncoding RNAs

Matsumoto1, Nakayama2 2018Cell Struct. Funct. 582480Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstract

CircRNAwrap – a flexible pipeline for circRNA identification, transcript prediction, and abundance estimation

Li1, Bu2, Zhao3 2019FEBS Letters270100Get access via publisherAdd to dashboardCite Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. Show abstract Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task. show abstractScite is an AI-powered research tool that helps researchers better discover and evaluate scientific literature through Smart Citations—a revolutionary system that shows whether articles support, contrast, or simply mention a given claim. Founded in 2018, and now part of Research Solutions, Scite has indexed over 1. 4 billion citations and partnered with more than 30 major publishers to provide researchers with unparalleled access to scientific literature. With its Scite Assistant, Smart Citation Index, and advanced search capabilities, the platform addresses critical challenges such as information overload and research reproducibility. Trusted by two million active users worldwide, Scite is reshaping how researchers interact with scholarly content—building ethical, transparent AI tools that support rigorous, copyright-compliant research.